Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation

Neuroreport
H W ChengT H McNeill

Abstract

Stathmin (p19) is developmentally regulated as a neural-enriched phosphoprotein associated with neurite outgrowth and synaptic formation during cell proliferation and differentiation, and remains highly abundant in adult rat brain. Whether stathmin is involved in injury-induced reactive synaptogenesis in adult rat was examined in this study. Following unilateral cortical lesion, a significant increase in stathmin mRNA expression was found in the cells of contralateral homotypic cortex and in the subventricular zone of the lateral ventricle. This increase coincided in time with the corticostriatal axon sprouting and synaptic remodeling previously found in denervated striatum. Our data suggest that stathmin plays an important role in regulation of reactive synaptogenesis in adult brain.

References

Aug 1, 1991·Trends in Biochemical Sciences·A Sobel
Sep 21, 1984·Science·C W Cotman, M Nieto-Sampedro

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Citations

Oct 23, 2002·Journal of Neuroscience Research·Nozomu Mori, Hiroshi Morii
Mar 23, 2004·Behavioural Brain Research·Scott D Bury, Theresa A Jones
Mar 26, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ann-Christine EhlisTobias J Renner
Oct 24, 2003·The Journal of Comparative Neurology·Thomas H McNeillCharles K Meshul
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kunlin JinDavid A Greenberg

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