Upregulation of the long non-coding RNA SNHG1 predicts poor prognosis, promotes cell proliferation and invasion, and reduces apoptosis in glioma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qiang WangFeng Zhi

Abstract

Long non-coding RNAs (lncRNAs), which are non-coding RNAs with a length above 200 nucleotides, have emerged as novel and important gene expression modulators in carcinogenesis. Recent evidence indicates that the lncRNA small nucleolar RNA host gene 1 (SNHG1) functions as an oncogene in several types of human cancers. However, its function in the development of glioma remains unknown. The aim of this research was to investigate the clinical aspects and biological mechanisms of SNHG1 in glioma. SNHG1 expression was measured in glioma tissues and cell lines by quantitative real-time PCR (qRT-PCR). The association between SNHG1 expression in tissues and clinicopathological characteristics and prognosis in glioma patients was also explored. Gain-of-function and loss-of-function studies using SNHG1 cDNA and siRNA, respectively, were used to investigate the role of SNHG1 in cell proliferation, invasion and apoptosis in glioma. SNHG1 was highly expressed in glioma tissues, and its upregulation was closely related to old age. Kaplan-Meier analysis showed that high expression of SNHG1 was significantly associated with poor overall survival (OS). Functionally, ectopic expression of SNHG1 enhanced cell proliferation and cell invasion and r...Continue Reading

Citations

Jan 28, 2018·Functional & Integrative Genomics·Yuwei ZhangQi Liao
Feb 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qingchun LuTao Ren
Dec 28, 2019·Current Stem Cell Research & Therapy·Jicheng WangZhi Yi
Sep 5, 2020·Journal of Cellular and Molecular Medicine·Wei XiangGuosong Jiang
Dec 26, 2018·Cancers·Ryte RynkevicieneKestutis Suziedelis
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Sep 21, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yang LiuHongjuan Song
May 26, 2018·The International Journal of Biological Markers·Qiang MengYang Sun
Dec 3, 2020·Cancer Management and Research·Ren-Duan CaiHong-Tao Lv
Dec 20, 2020·International Journal of Molecular Sciences·Leticia Moreno-GarcíaRosario Osta
Jun 13, 2021·Cell Biochemistry and Biophysics·Yishan He, Xinguang Qiu
Nov 17, 2021·Critical Reviews in Food Science and Nutrition·Mina HomayoonfalBahman Yousefi

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