Upregulation of the Long Noncoding RNA SNHG3 Promotes Lung Adenocarcinoma Proliferation

Disease Markers
Liang LiuXinhong He

Abstract

Lung cancer is the leading cause of cancer-associated mortalities worldwide. Non-small-cell lung cancer (NSCLC) is the main reason for cancer-relevant death and constitutes 80% of lung cancer cases. Long noncoding RNAs (lncRNAs) have been found to be related to different kinds of cancer. Long noncoding RNAs played important roles in regulating the pathological and physiological processes of numerous cancers. To explore novel lung adenocarcinoma-associated lncRNAs, we analyzed the TCGA database and found that the lncRNA SNHG3 was significantly upregulated in lung adenocarcinoma. Bioinformatic analysis showed that SNHG3 may play key roles in regulating RNA splicing, tRNA processing, signal transduction, cell adhesion, transcription, and apoptosis. We also performed functional experiments to explore the roles of SNHG3 in lung adenocarcinoma cells. We found that SNHG3 promoted proliferation, cell cycle, and suppressed cell apoptosis of lung adenocarcinoma, suggesting that SNHG3 acted as an oncogene in lung adenocarcinoma. We believe that this study will provide a potential new therapeutic and prognostic target for lung adenocarcinoma.

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Citations

Jul 1, 2020·Journal of Cellular and Molecular Medicine·Guangcheng DaiBoxin Xue
Aug 28, 2019·Journal of Cellular Biochemistry·Linqiang PengHongli Xin
Apr 17, 2021·Frontiers in Molecular Biosciences·Yu CaoChunjing Li
May 26, 2021·Technology in Cancer Research & Treatment·Yongqun LiJiguang Meng
Jul 27, 2021·Journal of Healthcare Engineering·Baojie KangYing Zhang

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Methods Mentioned

BETA
Reverse Transcription PCR
PCR
transfection
GTPase

Software Mentioned

STRING
NONCODE
Cytoscape
Targetscan
MAS

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