Upregulation of the Tim-3/Gal-9 pathway and correlation with the development of preeclampsia

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hai-Yan HaoDong-Rui Deng

Abstract

It is well documented that an imbalance in immune tolerance at the maternal-fetal interface is likely to play an essential role in the etiology of preeclampsia. However, the mechanisms underlying immune tolerance during preeclampsia are still poorly understood. Tim-3, a Th1-specific cell surface molecule, is a relatively newly described molecule with important immunological functions. It can regulate Th1 responses with its ligand galectin-9 (Gal-9), and has become an attractive candidate for exploring the pathogenesis of preeclampsia. Twenty normal pregnancies and 20 preeclamptic pregnancies were enrolled in the present study. We examined the expression and function of Tim-3/Gal-9 in decidual tissue at the RNA and protein levels. In order to analyze their correlation with the development of preeclampsia, we measured the expression of Tim-3 on peripheral blood leukocytes using flow cytometry. IFN-γ, IL-10, and IL-17 in the peripheral blood plasma were measured by ELISA. Tim-3/Gal-9 was upregulated in decidual tissue of preeclamptic vs. normotensive pregnancies. There was a significantly increased Th1 and Th17 response in PE as demonstrated by the upregulated levels of IFN-γ/IL-17, whereas IL-10 secreted by Th2 cells was sharply ...Continue Reading

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Citations

Oct 30, 2016·Journal of Reproductive Immunology·Xiao-Hui HuAi-Hua Liao
Mar 17, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Xiang KongXiaotong Zhu
Sep 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Giovanni SistiSteven S Witkin
Aug 31, 2020·Hypertension·Ellen MenkhorstEva Dimitriadis
Apr 1, 2020·Frontiers in Oncology·Valentina BrunoEnrico Vizza
Sep 2, 2016·Journal of Biosciences·Sebastian John, Rashmi Mishra
May 7, 2019·Frontiers in Immunology·Eva MikoLaszlo Szereday
May 2, 2018·Current Hypertension Reports·Hajrunisa CubroVesna D Garovic
Jul 26, 2021·International Immunopharmacology·Leila Mohamed KhosroshahiLeili Aghebati-Maleki

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