Upregulation of tumor necrosis factor alpha and interleukin-1 beta in Q fever endocarditis.

Infection and Immunity
C CapoJ L Mege

Abstract

The occurrence of Q fever endocarditis likely involves some alterations in the responses of monocytes, the in vivo targets of Coxiella burnetii. To test this hypothesis, the production of the inflammatory cytokines tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 was assessed in monocytes from patients with Q fever endocarditis. Spontaneous transcription and secretion of tumor necrosis factor and interleukin-1 were significantly higher in patient monocytes than in healthy controls. The interleukin-6 transcripts were also upregulated in patient cells. Moreover, in patients with recent endocarditis exhibiting high titers of immunoglobulin G directed to C. burnetii in phase I, monocytes released significantly higher levels of tumor necrosis factor and interleukin-1 than in patients with stabilized endocarditis. Immunoglobulin G titers and the overproduction of tumor necrosis factor and interleukin-1 were significantly correlated. Hence, the overproduction of inflammatory cytokines might be a marker of disease activity.

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Citations

Feb 5, 1999·Clinical and Experimental Immunology·C CapoJ Mege
Jul 16, 2003·Annals of the New York Academy of Sciences·Eric GhigoJean-Louis Mege
Jul 23, 2003·Infection and Immunity·Masako AndohKatsuya Hirai
Aug 1, 2015·PloS One·Izabella Rodrigues AraújoMaria Carmo Pereira Nunes
Feb 28, 2015·The Journal of Infectious Diseases·Teske SchoffelenEsther van de Vosse
Nov 20, 2016·Clinical Microbiology Reviews·Carole EldinDidier Raoult
Nov 21, 2009·Microbiology·Antony Croxatto, Gilbert Greub
Apr 14, 2016·Infection and Immunity·Jodi F HedgesMark A Jutila
May 19, 2000·Infection and Immunity·J DellacasagrandeJ L Mege
Oct 4, 2008·Clinical Chemistry·Tanja VollmerJens Dreier
Feb 24, 2006·Infection and Immunity·Amélie HonstettreJean-Louis Mege
Oct 30, 2010·Journal of Medical Microbiology·P C F Oyston, C Davies
Jan 1, 1997·Clinical and Diagnostic Laboratory Immunology·F SabatierJ Sampol
Oct 9, 1999·Clinical Microbiology Reviews·M Maurin, D Raoult

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