Upright Cheyne-Stokes Respiration in Patients With Heart Failure.

Journal of the American College of Cardiology
Alberto GiannoniClaudio Passino

Abstract

Cheyne-Stokes respiration (CSR) is believed to only occur in supine and sleeping conditions, and thus, CSR treatment is applied to those specific states. Although CSR has also been described in patients with heart failure (HF) during wakefulness, its persistence in an upright position is still unknown. The purpose of this study was to assess the predictors, clinical correlates, and prognostic value of diurnal CSR in upright position. Outpatients with systolic HF underwent a comprehensive evaluation, including short-term respiratory monitoring with a head-up tilt test to investigate the presence of upright CSR, assessment of chemoreflex response to hypoxia and hypercapnia, and 24-h cardiorespiratory recording. At follow-up, cardiac death was considered as the endpoint. Of 574 consecutive patients (left ventricular ejection fraction 32 ± 9%; age 65 ± 13 years; 80% men), 195 (34%) presented supine CSR only, 82 (14%) presented supine and upright CSR, and 297 patients (52%) had normal breathing. Patients with upright CSR had the greatest apnea-hypopnea and central apnea index (at daytime and nighttime), the worst hemodynamic profile and exercise performance, increased plasma norepinephrine and N-terminal pro-B-type natriuretic pepti...Continue Reading

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Citations

Jul 16, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Alberto GiannoniClaudio Passino
Nov 27, 2020·European Journal of Preventive Cardiology·Piergiuseppe AgostoniGianfranco Sinagra
May 23, 2020·European Journal of Heart Failure·Alberto GiannoniClaudio Passino
Jun 13, 2020·Journal of the American College of Cardiology·Virend K Somers, Shahid Karim
Jun 5, 2021·American Journal of Respiratory and Critical Care Medicine·Chiara BorrelliAlberto Giannoni
Aug 28, 2021·Journal of the American College of Cardiology·Marat FudimJaved Butler
Oct 24, 2020·Journal of the American College of Cardiology·Marat Fudim, Anzhela Soloveva
Oct 24, 2020·Journal of the American College of Cardiology·Alberto GiannoniClaudio Passino

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