PMID: 9167968Feb 1, 1997Paper

Upstream and downstream of erythroid transcription factor GATA-1

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
M YamamotoJ D Engel

Abstract

All mature blood lineages in the peripheral circulation are derived from pluripotent haematopoietic stem cell. Progressive lineage-restriction of this stem cell is executed, in part, by the interplay and cross-talk between a host of lineage-restricted as well as ubiquitous transcription factors. To elucidate the regulatory mechanisms underlying the erythroid gene regulation, it is essential to understand how individual transcription factors contribute to the regulation of specific target genes, and how these erythroid transcription factor genes are regulated in turn. These key issues of mammalian development have been addressed by examining the activities controlling the prototype transcription factor, GATA-1. The transcriptional regulation of GATA-1 has been intensively investigated, thereby leading to the identification of its developmental stage-specific regulatory sequences. Loss-of-function mutant animals, combined with specific marking of the primitive and definitive erythroid lineages have also shed new insight into how GATA-1 activity is required in vivo at specific developmental stages. Procedures have also been developed for ascertaining whether or not the GATA-1 protein actually binds in vivo to regulatory GATA motif...Continue Reading

Citations

Sep 2, 1998·The EMBO Journal·S Cohen-KaminskyP H Roméo
Mar 24, 2005·Journal of Cellular and Molecular Medicine·Xiaofang Huo, Junwu Zhang
Oct 16, 2003·Molecular and Cellular Biology·Natasha RekhtmanArthur I Skoultchi
Oct 31, 2003·Molecular and Cellular Biology·Keizo NishikawaMasayuki Yamamoto
Dec 2, 2004·Molecular and Cellular Biology·Ritsuko ShimizuMasayuki Yamamoto
May 2, 2013·PloS One·Kari Furu, Arne Klungland
Jun 9, 2006·Immunologic Research·Yoshimichi Okayama, Toshiaki Kawakami
Mar 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huilin QiCatherine M Verfaillie
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Jul 4, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Junko WakabayashiMasayuki Yamamoto
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Jul 12, 2001·Annual Review of Biomedical Engineering·P W Zandstra, A Nagy
Dec 18, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kinuko OhnedaMasayuki Yamamoto
Dec 24, 2014·Molecular and Cellular Biology·Takashi MoriguchiMasayuki Yamamoto
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Sep 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiko MaedaKo Okumura
Nov 27, 2019·IUBMB Life·Laura GutiérrezJohn Strouboulis

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