PMID: 7025654Sep 1, 1981Paper

Uptake and asymmetric efflux of amino acids at maternal and fetal sides of placenta

The American Journal of Physiology
B M Eaton, D L Yudilevich

Abstract

Unidirectional uptake of eighteen amino acids into the syncytiotrophoblast was measured from both the maternal and fetal circulations of isolated dually perfused guinea pig placentas using a single-circulation, paired-tracer dilution technique. A bolus containing a tritiated amino acid and L-[14C]glucose (extracellular marker) was injected intra-arterially into one circulation, and both venous outflows were sequentially sampled. The maximal cellular uptake (Umax) on the injection side was determined from (1-[3H]/[14C]) values and used to calculate the unidirectional influx. Umax values for neutral and basic amino acids ranged between 15 and 58% and were similar on both sides of the trophoblast. Uptake of the acidic amino acids and taurine was minimal. Amino acid influx from either circulation was followed by rapid tracer backflux and transplacental transfer. Tracer efflux was asymmetric and preferentially directed towards the fetal side. It is suggested that amino acid transport systems are present on both surfaces of the placenta and that net transfer from mother to fetus is the result of asymmetric efflux from the trophoblast.

References

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Citations

Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·I WesslerK Racké
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S Camelo JrS M Jorge
Feb 13, 2008·Journal of Neuroendocrinology·J K Cleal, R M Lewis
Jan 20, 1999·European Journal of Clinical Investigation·B M Eaton, S R Sooranna
Apr 3, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·P G RadmacherD H Adamkin
Feb 1, 1989·Alcoholism, Clinical and Experimental Research·S SchenkerG I Henderson
Dec 1, 1982·Pflügers Archiv : European journal of physiology·J StulcJ Svihovec
Oct 11, 2005·Acta Paediatrica. Supplement·William W Hay
Apr 27, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J S CameloF E Martinez
Oct 29, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Erick RidoutPatti J Thureen
Dec 8, 2000·The Journal of Biological Chemistry·M P McGee, T Chou
Jun 6, 2000·Advanced Drug Delivery Reviews·G T KnippM J Soares
Aug 15, 2000·Placenta·B M Eaton, S R Sooranna
Jun 25, 1984·Biochimica Et Biophysica Acta·P Truman, H C Ford
Sep 9, 1985·Biochimica Et Biophysica Acta·D L Yudilevich, J H Sweiry
Jan 30, 1989·Biochimica Et Biophysica Acta·C P Wheeler, D L Yudilevich

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