Uptake and clearance of inhalation anesthetics in man

Drug Metabolism Reviews
V Fiserova-Bergerova, D A Holaday

Abstract

The uptake, distribution, and clearance of inhaled vapors is governed by rules of partial pressure equilibration in a multicompartmental system. Since halogenated anesthetic agents are not soluble in water, biotransformation is their only clearance pathway during anesthesia. When apparent steady state is reached, the rate of overall metabolism can be determined from the pulmonary uptake rate. As a result of metabolism, pulmonary uptake increases but the concentration of inhaled vapor in blood and tissues decreases, and only a fraction of uptake is exhaled following anesthesia. Uptake and pulmonary clearance of five halogenated anesthetic agents were studied in 45 surgical patients. The susceptibility to biotransformation increases in the following order: isoflurane, enflurane, halothane, fluroxene, methoxyflurane.

References

Aug 1, 1978·Anesthesiology·M A ZumbielD A Holaday
Jan 1, 1979·Drug Metabolism Reviews·D A Holaday, V Fiserova-Bergerova
Feb 1, 1977·British Journal of Anaesthesia·A Feingold, D A Holaday
Sep 1, 1975·Anesthesiology·D A HoladayM A Zumbiel
May 1, 1976·Anesthesiology·N YoshimuraV Fiserova-Bergerova
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Jan 1, 1974·British Journal of Industrial Medicine·V Fiserova-BergerovaK Singhal
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Mar 1, 1971·Anesthesiology·D C SawyerD Impelman
Jan 1, 1963·Journal of Applied Physiology·W W MAPLESON

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Citations

Sep 30, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Joachim D Pleil
Jan 1, 1992·Drug Metabolism Reviews·V Fiserova-Bergerova
May 1, 1981·Critical Reviews in Toxicology·M E Andersen
Jan 1, 1988·Critical Reviews in Toxicology·L S Kaminsky, J M Fraser
Jan 1, 1984·Drug Metabolism Reviews·V Fiserova-BergerovaF J Di Carlo
Jan 1, 1979·Drug Metabolism Reviews·D A Holaday, V Fiserova-Bergerova
Jan 1, 1982·Drug and Chemical Toxicology·I W DavidsonJ C Parker
Mar 30, 1984·Toxicology and Applied Pharmacology·J C Ramsey, M E Andersen
Nov 1, 1988·Toxicology and Applied Pharmacology·D J PaustenbachM E Andersen
Nov 1, 1989·IEEE Transactions on Bio-medical Engineering·J S JenkinsD S Ward
Sep 3, 2016·Archives of Toxicology·Joachim D Pleil
Feb 1, 2003·Toxicology Letters·Melvin E Andersen
Jul 29, 1987·Biochimica Et Biophysica Acta·A M WyrwiczP Eisele

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