PMID: 2505755Jul 1, 1989Paper

Uptake and degradation in vivo and in vitro of laminin and nidogen by rat liver cells

The Biochemical Journal
B SmedsrødS Johansson

Abstract

Laminin antigens are known to be present in the blood of normal individuals. In the present study we have investigated the fate of laminin-related molecules in the circulation. After intravenous injection in rats, the native laminin-nidogen complex, as well as the separated proteins, were rapidly eliminated from the blood (half-lives 2-10 min) by the liver. The large laminin fragments E1 and E8 (Mr 400,000 and 280,000 respectively), which contain the major cell-adhesion-promoting activities of laminin, were also cleared from the blood mainly by the liver, but the rate of uptake was an order of magnitude lower for these fragments than for laminin. This indicates that the uptake of laminin did not occur via cell-adhesion receptors. The endothelial cells of liver were the most important cell type in the uptake of laminin-nidogen complex, nidogen, laminin and fragment E1, whereas the parenchymal cells were responsible for more than 50% of the uptake of E8 in the liver. Studies in vitro with cultured liver endothelial cells and parenchymal cells demonstrated that the ligands were endocytosed and degraded independently of plasma factors. The results reveal that the level of laminin antigens in blood is a very complex parameter. It is...Continue Reading

Citations

Jan 18, 2011·European Journal of Internal Medicine·Argiro VoumvourakiElias Kouroumalis
Sep 19, 2003·Biochemical and Biophysical Research Communications·Dmitri N SvistounovBard H Smedsrod
Aug 1, 1994·Leukemia Research·H Hasselbalch, P Junker
Mar 24, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M CatarinoE R Parise
Jul 3, 2008·World Journal of Gastroenterology : WJG·Heitor Rosa, Edison Roberto Parise
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A Toth, P Thomas
Oct 1, 1990·European Journal of Clinical Investigation·G AdlerA M Gressner
Jul 1, 1993·Gut·J CollazosJ Genollá
Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen Kristine SørensenBård Smedsrød
Dec 1, 1991·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·J KropfH Lennartz
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Alfons SegarraSimó Schwartz

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