Uptake and fate of ozone in the respiratory tract

Toxicology Letters
F J Miller

Abstract

Ozone (O3) is a ubiquitous pollutant with an array of established effects following acute and chronic exposure. Absorption of O3 occurs in all regions of the respiratory tract, but injury to the pulmonary region appears to be of greatest concern because of the susceptibility of this region to the development of chronic disease. Processes that affect the uptake and transport of O3 and available dosimetry models are briefly reviewed prior to discussing recent experimental dosimetry data in laboratory animals and humans. Dosimetry model predictions are compared with experimental data, and an example is provided that illustrates the potential for such models to contribute to our understanding of toxicological results.

References

Feb 1, 1992·American Journal of Respiratory Cell and Molecular Biology·K C StoneJ D Crapo
Jun 1, 1992·Computers and Biomedical Research, an International Journal·S C HuJ S Ultman
Oct 1, 1988·Toxicology and Applied Pharmacology·M J WiesterD L Costa
Aug 1, 1972·Archives of Environmental Health·E Yokoyama, R Frank

❮ Previous
Next ❯

Citations

Mar 1, 2012·International Archives of Occupational and Environmental Health·Iva HůnováMartin Braniš
Feb 15, 2002·Lancet·Rob McConnellJohn M Peters
Feb 4, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daher Ibrahim AiboJack R Harkema
May 12, 2015·Critical Reviews in Toxicology·Julie E GoodmanFerdinand J Venditti
Sep 27, 2014·Critical Reviews in Toxicology·Robyn L PrueittJulie E Goodman
Sep 27, 2014·Critical Reviews in Toxicology·Julie E GoodmanFerdinand J Venditti
Apr 20, 2004·Environmental Pollution·D KleyS Krupa
Aug 30, 2016·Inhalation Toxicology·Robyn L Prueitt, Julie E Goodman
Mar 14, 2002·Toxicologic Pathology·Richard W LewisFrancis Carpanini
Oct 8, 2009·Molecular and Cellular Biochemistry·Rama Surya Prakash PerepuRajat Sethi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.