PMID: 2117922Aug 1, 1990Paper

Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis

The Biochemical Journal
Philip C CalderE A Newsholme

Abstract

Murine thioglycollate-elicited peritoneal macrophages were cultured in the presence of a variety of fatty acids added as complexes with bovine serum albumin. All fatty acids tested were taken up readily by the cells and both neutral and phospholipid fractions were enriched with the fatty acid provided in the medium. This generated a range of cells enriched in saturated, monounsaturated or polyunsaturated fatty acids, including n-3 acids of fish oil origin. Saturated fatty acid enrichment enhanced macrophage adhesion to both tissue culture plastic and bacterial plastic compared with enrichment with polyunsaturated fatty acids. Macrophages enriched with the saturated fatty acids myristate or palmitate showed decreases of 28% and 21% respectively in their ability to phagocytose unopsonized zymosan particles. Those enriched with polyunsaturated fatty acids showed 25-55% enhancement of phagocytic capacity. The greatest rate of uptake was with arachidonate-enriched cells. Phagocytic rate was highly correlated with the saturated/unsaturated fatty acid ratio, percentage of polyunsaturated fatty acid and index of unsaturation, except for macrophages enriched with fish-oil-derived fatty acids; they showed lower phagocytic activity than e...Continue Reading

Citations

Apr 2, 2013·Research in Veterinary Science·Shyamala ThirunavukkarasuRichard J Whittington
Dec 26, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lynette K RogersSarah A Keim
May 16, 2012·Prostaglandins & Other Lipid Mediators·Benjamin J BeldaJohn P Vanden Heuvel
Aug 6, 2011·European Journal of Pharmacology·Philip C Calder
Jul 30, 2011·Chemistry and Physics of Lipids·David N McMurrayRobert S Chapkin
Jul 19, 2011·The Journal of Nutritional Biochemistry·Benjamin J BeldaJohn P Vanden Heuvel
Oct 5, 2010·The Veterinary Journal·Cristina LecchiFabrizio Ceciliani
Nov 26, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Philip C Calder
Mar 5, 2016·Scientific Reports·Mehboob AliLynette K Rogers
Apr 21, 2009·International Journal of Food Microbiology·Uma BabuRichard B Raybourne
Jul 22, 2014·The American Journal of Pathology·Hirofumi MiyazakiYuji Owada
Oct 28, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philip C Calder
Nov 23, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Philip C Calder
Sep 5, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hertzel SalmanHanna Bessler
Sep 30, 2015·Progress in Lipid Research·Julie Boisramé-HelmsFerhat Meziani
Apr 1, 1994·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P C CalderE A Newsholme
Nov 5, 2005·Experimental and Molecular Pathology·Meir DjaldettiHanna Bessler
Jun 28, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michelle VersleijenGeert Wanten
Mar 20, 2015·Animal : an International Journal of Animal Bioscience·M ĐidaraM Šperanda
May 20, 2015·European Journal of Pharmacology·Julia Schumann
May 10, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T R CampoioR Otton
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S SudheendranR J Deckelbaum
May 9, 2006·Seminars in Immunology·Katherine Anne Siminovitch
May 28, 2005·Cellular Immunology·Sandro J R BonattoLuiz C Fernandes
Jun 29, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Dan L WaitzbergThiago Manzoni Jacintho
Jul 10, 1998·The Proceedings of the Nutrition Society·E A Miles, P C Calder
Mar 31, 2001·The British Journal of Nutrition·E A MilesP C Calder
Sep 26, 2002·The Proceedings of the Nutrition Society·Philip C Calder

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