Uptake and metabolism of plasma-derived erucic acid by rat brain.

Journal of Lipid Research
Mikhail Y Golovko, Eric J Murphy

Abstract

We examined the ability of erucic acid (22:1n-9) to cross the blood-brain barrier (BBB) by infusing [14-14C]22:1n-9 (170 microCi/kg, iv and icv) into awake, male rats. [1-14C]arachidonic acid (20:4n-6) [intravenous (i.v.)] was the positive control. After i.v. infusion, 0.011% of the plasma [14-14C]22:1n-9 was extracted by the brain, compared with 0.055% of the plasma [1-14C]20:4n-6. The [14-14C]22:1n-9 was extensively beta-oxidized (60%), compared with 30% for [1-14C]20:4n-6. Although 20:4n-6 was targeted primarily to phospholipid pools, 22:1n-9 was targeted to cholesteryl esters, triglycerides, and phospholipids. When [14-14C]22:1n-9 was infused directly into the fourth ventricle of the brain [intracerebroventricular (i.c.v.)] for 7 days, 60% of the tracer entered the phospholipid pools, similar to the distribution observed for [1-14C]20:4n-6. This demonstrates plasticity in the ability of the brain to esterify 22:1n-9 in an exposure-dependent manner. In i.v. and i.c.v. infused rats, a significant amount of tracer found in the phospholipid pools underwent sequential rounds of chain shortening and was found as [12-14C]20:1n-9 and [10-14C]oleic acid. These results demonstrate for the first time that intact 22:1n-9 crosses the BB...Continue Reading

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Citations

Mar 20, 2008·Lipids·Cameron C MurphyMikhail Y Golovko
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Hugo W MoserGerald V Raymond
Feb 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Robin E Duncan, Richard P Bazinet
Jan 19, 2016·Pharmacology, Biochemistry, and Behavior·Eunji KimJong Hoon Ryu
Jan 29, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tupur RahmanRichard P Bazinet
Feb 25, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Chuck T ChenRichard P Bazinet
Oct 22, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Chuck T ChenRichard P Bazinet
Aug 8, 2013·Journal of Neurochemistry·Sarah K OrrRichard P Bazinet
Nov 26, 2013·Journal of Neurochemistry·Stephen A BroseMikhail Y Golovko
May 27, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyu-Bong KimByung-Mu Lee
Feb 3, 2016·British Journal of Clinical Pharmacology·Mariam A AhmedGerald V Raymond
Nov 30, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bela R TurkAnn B Moser
Oct 19, 2019·Metabolic Brain Disease·Meric A AltinozEmily Hacker
Jan 8, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bela R TurkAnn B Moser
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Oct 16, 2020·Nutritional Neuroscience·J B Senthil Kumar, Bhawna Sharma

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