PMID: 22571479May 11, 2012Paper

Uptake and metabolism of the short-chain fatty acid butyrate, a critical review of the literature

Current Drug Metabolism
Stuart M Astbury, Bernard M Corfe

Abstract

Butyrate is a short-chain fatty acid (SCFA) formed by bacterial fermentation of fibre in the colon, and serves as an energy source for colonocytes. The action of butyrate as a histone deacetylase inhibitor (HDACi) has led to a number of clinical trials testing its effectiveness as a potential treatment for cancer. The biology of butyrate transport is therefore relevant to both its physiological and pharmacological benefits. This review of the literature was carried out to assess the evidence for both the uptake and metabolism of butyrate, in an attempt to determine possible mechanism (s) by which butyrate can act as an HDACi. It is noted that although uptake and metabolism are well characterised, there are still significant gaps in the knowledgebase around the intracellular handing of butyrate, where assumptions or dated evidence are relied upon.

Citations

Oct 2, 2013·Trends in Parasitology·Pauline D Scanlan, Christen R Stensvold
Jan 4, 2013·Nutrition Reviews·Manoj KumarBirbal Singh
Apr 19, 2016·Best Practice & Research. Clinical Gastroenterology·Pawel R Kiela, Fayez K Ghishan
Dec 1, 2015·Frontiers in Pharmacology·Bhanu Priya Ganesh, James Versalovic
Aug 6, 2015·Nutrition Research and Practice·Sang-Woon ChoiSimonetta Friso
Jun 28, 2016·Neurochemistry International·Roman M StillingJohn F Cryan
Jul 31, 2016·BMC Gastroenterology·Mingming ZhangChenggong Yu
Nov 23, 2017·Medicine and Science in Sports and Exercise·Jacob M AllenJeffrey A Woods
Feb 2, 2019·Gut Microbes·Alyssa DaltonMicah Zuhl
May 14, 2020·Journal of the International Society of Sports Nutrition·Alex E MohrJose Antonio
Aug 14, 2019·Bioorganic Chemistry·Meiling HuangRui Ling
Oct 23, 2020·International Journal of Molecular Sciences·Xavier Remesar, Marià Alemany
Apr 4, 2021·International Journal of Molecular Sciences·Elisabetta Di FedeCristina Gervasini
Jun 18, 2021·Journal of Pediatric Gastroenterology and Nutrition·Cilius Esmann FonvigJens-Christian Holm

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