PMID: 6406931Mar 1, 1983Paper

Uptake and retention of [3H]adrenaline by central monoaminergic neurons: a light- and electron-microscope radioautographic study after intraventricular administration in the rat

Neuroscience
O Bosler, L Descarries

Abstract

Paraventricular and paracisternal regions of adult rat central nervous system were investigated by light- and electron-microscope radioautography after intraventricular administration of tritiated adrenaline. In tissue primarily fixed by glutaraldehyde perfusion and post-fixed by immersion in osmium tetroxide, there were no aggregates of silver grains indicative of intraneuronal accumulation of the tracer, except over perivascular nerve terminals at the base of the brain. In contrast, when both fixation and postfixation were carried out by rapid vascular perfusion, preferentially labeled nerve cell bodies and axonal varicosities (i.e. terminals) were detected in various anatomical areas known to contain dopaminergic and/or noradrenergic neurons. Serotoninergic axonal varicosities in the supraependymal plexus and subcommissural organ, as well as a small group of nerve cell bodies of undetermined chemical identity in the n. paraventricularis thalami were also found to be labeled. Addition of a ten-fold higher concentration of non-radioactive serotonin to the solution of [3H]adrenaline suppressed the reactivity in the subcommissural organ and the supraependymal plexus but had no such effect elsewhere in brain. Lesioning of the nig...Continue Reading

References

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