PMID: 8947540Nov 1, 1996Paper

Uptake and retention of nitroimidazole-carboranes designed for boron neutron capture therapy in experimental murine tumours: detection by 11B magnetic resonance spectroscopy

International Journal of Radiation Biology
P J WoodM D Threadgill

Abstract

Two novel nitroimidazole-carboranes were examined for their uptake and retention in two experimental murine solid tumours and in some normal tissues, using in vivo 11B magnetic resonance spectroscopy. The compounds were injected i.p. at 0.8mmol/kg into mice bearing either the SCCVII/Ha squamous cell carcinoma or KHT sarcoma implanted intradermally on the mouse back. Boron from a polyether-isoxazole linked nitroimidazole-carborane (compound 1) was detectable in both SCCVII/Ha and KHT tumours at 3 and 7 h after injection. The signal from the liver at these times was greater than that from the tumour but only a weak signal was obtained from the brain. At 24 h after injection the tumour signal was still present, as was that from the liver, which appeared to have increased over that for the earlier times. Signal from the brain had disappeared by 24 h. Boron from a polyether-carbamate linked nitroimidazole-carborane (compound 2) was also detectable in both tumours at all times tested, and again was present in the liver. In addition, the 11B signal was detectable from the mouse brain, at early times, but was undetectable at 24 h. These preliminary data indicate that nitroimidazole-carboranes are taken up and retained in experimental m...Continue Reading

References

Oct 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G W KabalkaP Bendel
Oct 1, 1983·The British Journal of Radiology·B M Garrecht, J D Chapman
Jan 1, 1980·Biochemical Pharmacology·K A KennedyA C Sartorelli
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·H Hatanaka, Y Nakagawa
Mar 30, 1994·International Journal of Radiation Oncology, Biology, Physics·J CoderreD Gash
Jul 15, 1993·International Journal of Radiation Oncology, Biology, Physics·P OkunieffP Vaupel
Mar 29, 1996·Journal of Medicinal Chemistry·D H SwensonR L Metzger
May 1, 1994·Nuclear Medicine and Biology·D S WilburT W Griffin

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Citations

Mar 14, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P BendelY Salomon
Mar 17, 2005·NMR in Biomedicine·Peter Bendel
Dec 14, 2002·Chemical Communications : Chem Comm·Christophe FrixaMichael D Threadgill
Dec 26, 2001·Chemical Reviews·H Ali, J E van Lier
Feb 19, 2002·Chemical Reviews·Albert H. SolowayJ. Gerald Wilson

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