PMID: 6165633Apr 1, 1981Paper

Uptake, metabolism and action of triiodothyronine in calf-thyroid slices

Molecular and Cellular Endocrinology
G J JuvenalN Altschuler

Abstract

T3 and T4 at 10(-6)M caused a significant inhibition on [3H]uridine incorporation into RNA in calf-thyroid slices. This effect was not altered by addition of 10(-3) M PTU or MMI. The metabolism of 125I-T3 was studied under the same conditions. There was a very slight dehalogenation after 60 min (less than 5%) which was inhibited by PTU. The time course of the uptake of labeled T3 showed a temperature dependence, and this uptake was not altered by 10(-6)M KI, 1-T4, DIT or MIT, thus indicating specificity. The early phase of labeled T3 entrance into the cell was inhibited by the addition of colt T3 in a dose- dependent manner from 10(-9) to 10(-5)M. Slices previously stimulated by cAMP or CGMP showed a significant increase in the uptake of labeled T3. ATPase activity or ATP, protein or RNA synthesis does not seem to play a role in this process. The relationship between substitutions in the thyronine molecule and its biological action on RNA synthesis was also studied, and some preliminary conclusions were drawn. These studies demonstrate that T3 has a direct action on the thyroid.

References

Oct 1, 1976·Acta Endocrinologica·M A PisarevD L Kleiman de Pisarev
Feb 1, 1977·Acta Endocrinologica·M A Pisarev, D L de Pisarev
Oct 1, 1978·Acta Endocrinologica·D L Kleiman de PisarevG J Juvenal
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Jun 1, 1976·Acta Endocrinologica·M A Pisarev, L O Aiello
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Jan 1, 1952·Biochimica Et Biophysica Acta·J ROCHES LISSITZKY

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Citations

Dec 1, 1983·Molecular and Cellular Endocrinology·D Toru-DelbauffeM Pavlovic-Hournac
May 17, 1996·Molecular and Cellular Endocrinology·S Selmi-Ruby, B Rousset
Aug 29, 2016·Molecular and Cellular Endocrinology·Luciano E RossichGuillermo J Juvenal
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·G BrentaM A Pisarev
Oct 1, 1985·Journal of Endocrinological Investigation·M A Pisarev
Nov 1, 1991·Journal of Endocrinological Investigation·D PasqualiJ B Field
Mar 23, 2010·Molecular and Cellular Endocrinology·Lisa ThomaszGuillermo J Juvenal

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