PMID: 11323244Apr 27, 2001Paper

Uptake of (188)Re-beta-naphthyl-peptide in cervical carcinoma tumours in athymic mice

Nuclear Medicine and Biology
C Arteaga de MurphyS Hernández-Gutiérrez

Abstract

Radiolabelled somatostatin analogues have been used in diagnostic and therapeutic nuclear medicine to treat cancerous tumours. Lanreotide, a cyclic octapeptide, beta-naphthyl-peptide, with antiproliferative action on human small cell lung carcinoma was (188)Re labelled and characterised, and its biodistribution was studied in mice. Molecular modelling indicates that the lipophilic radiopharmaceutical might be an oxo-rhenium (V) penta-coordinated complex. The implanted human cervical tumour of epidermoid origin was positive for cytokeratins and Vimentin. Uptake of (188)Re-labelled peptide in the implanted tumour in athymic mice was 6.2+/-2.9% and was rapidly cleared via the hepatobiliary system. (188)Re-beta-naphthyl-peptide might be a potential therapeutic agent.

References

May 31, 1988·Biochemical and Biophysical Research Communications·J E TaylorD H Coy
Jul 1, 1997·European Journal of Nuclear Medicine·A OtteH R Maecke
May 26, 1999·International Journal of Pharmaceutics·L Meléndez-AlafortL García-Salinas

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Citations

Nov 16, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M S DadachovE Dadachova
Jan 21, 2006·International Journal of Pharmaceutics·Eva M Molina-TrinidadHelgi Jung-Cook
Jul 8, 2010·The Journal of Pharmacy and Pharmacology·Eva M Molina-TrinidadGuadalupe Vertiz Serrano
Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romain EychenneNicolas Lepareur
Jul 21, 2006·The Journal of Physical Chemistry. B·Jorge A AscencioGerardo Canizal

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