Uptake of 203Hg2+ in the olfactory system in pike

Toxicology Letters
K Borg-Neczak, H Tjälve

Abstract

Inorganic mercury (203Hg2+) was applied to the olfactory chambers or was given i.v. to pike (Esox lucius) and the uptake of the metal in the olfactory system and the brain was examined by autoradiography and gamma spectrometry. Application of 203Hg2+ in the olfactory chambers resulted in an accumulation of the metal in the olfactory nerves and the anterior parts of the olfactory bulbs of the brain. The levels of 203Hg2+ in other brain areas, such as the telencephalon, the optic tecti and the cerebellum, remained low. Application of 203Hg2+ in only one olfactory chamber resulted in an uptake of the metal only in the ipsilateral olfactory nerve and olfactory bulb. Intravenous injection of the 203Hg2+ resulted in a labelling of the olfactory system and the brain, which was much lower than of the blood. These results indicate that the 203Hg2+ is taken up in the olfactory neurones from the olfactory receptor cells in the olfactory rosettes and is transported to the terminal parts of the olfactory neurones in the olfactory bulbs. The uptake of mercury as well as some other metals in the olfactory system may result in noxious effects and this may be an important component in the toxicology of metals in fish.

References

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Citations

Apr 15, 2008·Ecotoxicology·Richard D HandyCharles R Tyler
May 26, 2005·Medical Hypotheses·Robert J F Elsner, John G Spangler
Nov 14, 2003·Toxicology and Applied Pharmacology·Deepa B RaoDavid C Dorman
Apr 28, 1997·Toxicology Letters·J HenrikssonH Tjälve
Jul 1, 1995·Pharmacology & Toxicology·H TjälveK Borg-Neczak
Jun 13, 1998·Environmental Research·J Henriksson, H Tjälve
May 3, 2014·Journal of Toxicology and Environmental Health. Part a·Amy J SteuerwaldPatrick J Parsons
Nov 27, 2004·Otolaryngologic Clinics of North America·Urmen D Upadhyay, Eric H Holbrook
Sep 12, 2003·Environmental Science & Technology·Claude RouleauGuo-Lan Huang

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