Uptake of 3H-GABA (gamma-aminobutyric acid) and 3H-leucine in the pancreatic islets and substantia nigra of the rat

Experientia
Y OkadaH Taniguchi

Abstract

Isolated pancreatic islets and thin slices of substantia nigra (SN) of the rat were incubated in a medium containing 3H-GABA or 3H-leucine to test the activity of both tissues in the uptake of those substances. Pancreatic islets showed a low uptake of both 3H-GABA and 3H-leucine, but SN had a high activity in the uptake of 3H-GABA, though not for 3H-leucine. This suggests that GABA contained at high levels in the pancreatic islets some functional role other than in neurotransmission as in the central nervous system (CNS).

References

May 1, 1975·Biochemical Pharmacology·L L Iversen, J S Kelly
Dec 1, 1974·Journal of Neurochemistry·R J Drummond, A T Phillips
Jul 1, 1974·Physiological Reviews·S C Woods, D Porte

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Citations

Jul 7, 1992·Biochemical Pharmacology·M Michalik, M Erecińska
Sep 11, 1987·European Journal of Pharmacology·A Krantis, R K Harding
Jan 1, 1987·Neurochemistry International·P C CaronL J Cote

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