Uptake of 5-iododeoxyuridine as a measure of tumor growth and tumor inhibition.

Chemotherapy
E BonmassarA Goldin

Abstract

The DNA synthesis of tumor cells in spleen, lung and liver of mice bearing spontaneous or transplanted lymphomas or Lewis lung carcinoma was determined by measuring the uptake of 5-iododeoxyuridine labeled with iodine-125 (125IUdR). An in vitro uptake method was also developed to assess 125IUdR uptake of peripheral blood of leukemic animals. A direct relationship was found between isotope uptake values and the extent of neoplastic growth. The 125IUdR uptake method was found to be applicable to determination of inhibition of tumor growth in drug-treated animals and in pre-sensitized allogeneic hosts and to measurement of regression in non-sensitized allogeneic mice.

Citations

Apr 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A BonmassarA Goldin
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E ZocchiA De Flora
Sep 1, 1981·The Journal of Clinical Investigation·J ShapiroS Segal
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B SveinbjørnssonB Smedsrød
Apr 1, 1982·European Journal of Cancer & Clinical Oncology·Y RonS Segal
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·A BonmassarE Bonmassar

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