PMID: 6113269May 1, 1981Paper

Uptake of exogenous glutamate and aspartate by circumventricular organs but not other regions of brain

Journal of Neurochemistry
M T PriceS Buchsbaum

Abstract

Glutamate (Glu) and aspartate (Asp) concentrations in blood and selected regions of brain were measured at sequential intervals over a 3-h period following subcutaneous administration of Glu, Asp, or Glu plus Asp (2 mg/g body wt) to 4-day old mouse or rat pups. Marked serum elevations of the administered amino acids (peak values exceeding 200 times control levels) were detected within 1 h. In circumventricular organ (CVO) regions of brain, which are thought to have no blood-brain barriers, a sharp and steady increase times higher than control levels) occurred during a 15-120 min interval, whereas no appreciable increase were detected in other brain regions. When 2 mg/g Glu plus 2 mg/g Asp were administered, CVO tissue concentrations of each amino acid rose to approximately the same level obtained when the individual amino acids were given. It is concluded that blood-brain barriers preventing net entry of Glu or Asp into brain proper are relatively well established by the 4th postnatal day in rodents, but that CVO brain regions lack such barriers; selective access of blood-borne Glu or Asp to CVO neurons explains why these neurons are selectively destroyed by systemic administration of these neurotoxic amino acids.

References

Aug 1, 1978·Neurochemical Research·E G McGeer, P L McGeer
Jan 1, 1976·Advances in Experimental Medicine and Biology·M W Brightman, R D Broadwell
Feb 15, 1975·British Medical Journal·E D Gilby, K J Taylor
Jan 27, 1978·Brain Research·J W Olney, T de Gubareff
Jan 1, 1976·Advances in Experimental Medicine and Biology·J W Olney
Jan 14, 1977·Brain Research·J W OlneyT D Gubareff
Oct 1, 1975·The American Journal of Physiology·A W ChanO H Lowry
Jun 14, 1974·Nature·F A HennA Hamberger
Jan 1, 1971·Journal of Neuropathology and Experimental Neurology·J W Olney
Oct 1, 1957·Neurology·W A HIMWICHM L ALLEN
Feb 1, 1959·Journal of Neurochemistry·A LAJTHAH WAELSCH

❮ Previous
Next ❯

Citations

Jan 1, 1987·Acta Neuropathologica·L TóthG W Kreutzberg
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·A Stricker-KrongradC Burlet
Sep 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M F WiaterS Ritter
Sep 1, 1995·Environmental Health Perspectives·P M Rodier
Jul 3, 2009·The American Journal of Clinical Nutrition·Richard A Hawkins
Nov 20, 2013·Neurotoxicity Research·Piotr MaciejakAdam Płaźnik
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Oct 16, 2016·Biology·Richard A Hawkins, Juan R Viña
Nov 1, 1986·Acta Neurologica Scandinavica·B Engelsen
May 1, 1986·Nutrition Reviews·W M Pardridge
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
May 17, 2002·Journal of Applied Physiology·Yijiang Shi, Evelyn H Schlenker
Mar 29, 2000·The Journal of Nutrition·Q R Smith
Mar 1, 1983·The American Journal of Physiology·J M Pell, E N Bergman
May 18, 2021·Frontiers in Cardiovascular Medicine·Richard MprahQiao Weili

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.