Uptake of FH by two types of scavenger-like receptors in rat liver parenchymal cells in primary culture

Biological & Pharmaceutical Bulletin
Takatoshi NakamuraJun Watanab

Abstract

Several anionic proteins that are known to be substrates of scavenger receptors documented in the literature were selected and tested for their effects on the uptake of fractionated heparin (FH), an anionic macromolecular drug. The tests were made in rat liver parenchymal cells to characterize scavenger-like receptors involved in FH uptake, probing into substrate recognition characteristics in comparison with those of scavenger receptors. Although the uptake of FH was completely inhibited by dextran sulfate, a typical substrate of scavenger receptors, suggesting that scavenger-like receptors that have affinity for some anionic macromolecules are responsible for the uptake, it was not inhibited by acetylated low density lipoprotein (Ac-LDL), another typical substrate. Thus, the scavenger-like receptors were suggested to be different from the major scavenger receptors of classes A and B that are known to be sensitive to Ac-LDL. The uptake of FH was only partially inhibited by maleylated bovine serum albumin (Mal-BSA), suggesting that the scavenger-like receptors can be classified into two types in terms of sensitivity to Mal-BSA. The Mal-BSA-sensitive receptor was also found to be sensitive to oxidized low density lipoprotein (Ox...Continue Reading

References

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Citations

Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Hiroaki Yuasa, Jun Watanabe
Jun 12, 2008·Journal of Cellular Physiology·Edvaldo S TrindadeHelena B Nader
Nov 17, 2017·The Journal of Toxicological Sciences·Yoshihisa KatoMasakuni Degawa

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