Uptake of first two doses of human papillomavirus vaccine by adolescent schoolgirls in Manchester: prospective cohort study

BMJ : British Medical Journal
Loretta BrabinR McCann

Abstract

To assess the feasibility and acceptability of delivering a human papillomavirus (HPV) vaccine to adolescent girls. Prospective cohort study. 36 secondary schools in two primary care trusts in Greater Manchester, United Kingdom. 2817 schoolgirls in year 8 (12 and 13 year olds). Delivery of the bivalent vaccine at 0, 1, and 6 months over one school year. Vaccine uptake for doses 1 and 2 of a three dose schedule. Vaccine uptake was 70.6% (1989/2817) for the first dose and 68.5% (1930/2817) for the second dose. Uptake was significantly lower in schools with a higher proportion of ethnic minority girls (P<0.001 for trend) or higher proportion of girls entitled to free school meals (P=0.029 for trend). The main reason for parents' refusal of vaccination was insufficient information about the vaccine and its long term safety. Maintaining the vaccine schedule was challenging as 16.3% (dose 1) and 23.6% (dose 2) of girls missed their vaccination day and had to be offered alternative appointments. No serious adverse events were reported. Delivery of the first two doses of HPV vaccine to adolescent schoolgirls is encouraging, but the success of the vaccination programme depends on high coverage for the third dose.

References

Apr 19, 2003·BMJ : British Medical Journal·Elizabeth Middleton, Deborah Baker
Oct 23, 2004·Archives of Disease in Childhood·L A WallaceD J Goldberg
Sep 5, 2006·Vaccine·Gregory D ZimetBetania Allen
Feb 8, 2007·Vaccine·Laura A V MarlowJane Wardle
Aug 3, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Lisa RamboutDean Fergusson
Aug 19, 2007·Journal of Epidemiology and Community Health·Ruth E MixerDavid Newsom
Aug 25, 2007·BMJ : British Medical Journal·Angela E Raffle

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Citations

Mar 1, 2012·International Journal of Public Health·Emilien JeannotPhilippe Chastonay
Jan 25, 2012·Journal of Behavioral Medicine·Paul L ReiterNoel T Brewer
Mar 26, 2010·Journal of Community Health·Emily L McCave
Aug 6, 2011·Advances in Therapy·Sherri N Sheinfeld GorinRebecca B Perkins
Nov 12, 2013·Revue D'épidémiologie Et De Santé Publique·E JeannotP Chastonay
Aug 30, 2008·Lancet·Elizabeth Leyland
Jun 6, 2013·Nature Reviews. Clinical Oncology·Matti Lehtinen, Joakim Dillner
Aug 20, 2010·Sexual Health·Nguyen Quy NghiNguyen Tran Hien
Aug 20, 2010·Sexual Health·Ingrid T KatzDavid R Bangsberg
Aug 20, 2010·Sexual Health·Gregory R MooreRichard Charnigo
Apr 15, 2010·Journal of Health Communication·Alice ForsterJo Waller
Dec 22, 2009·Family Practice·Elizabeth C F BrownGeraldine M Leydon
Jul 12, 2011·The Journal of Infectious Diseases·Tjalke A WestraJan C Wilschut
Apr 24, 2010·Sexually Transmitted Diseases·Paul L ReiterNoel T Brewer
Oct 20, 2012·Public Health Nursing·Heather L GainforthAmy E Latimer-Cheung
Oct 7, 2011·The Journal of School Health·Sally B RoseBeverley A Lawton
Apr 26, 2008·BMJ : British Medical Journal·Jo Waller, Jane Wardle
May 24, 2008·BMJ : British Medical Journal·Gee Yen Shin
May 24, 2008·BMJ : British Medical Journal·Elizabeth C F Brown
Jul 22, 2008·BMJ : British Medical Journal·Mark JitW John Edmunds
Dec 17, 2009·Annual Review of Public Health·María E FernándezJessica A Kahn
Sep 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paul L ReiterNoel T Brewer
Mar 24, 2011·BMC Public Health·Varun M Kumar, David K Whynes
Nov 1, 2011·PloS One·Yumi Taylor DiAngiNoel T Brewer
Nov 13, 2012·PloS One·Rosario M BartoliniD Scott LaMontagne
Aug 2, 2013·The Journal of Family Planning and Reproductive Health Care·Harriet L BowyerJo Waller
Dec 18, 2013·Gynecologic Oncology·Jennifer L MossNoel T Brewer
Sep 22, 2010·European Journal of Pediatrics·Jeanet M KemmerenHester E de Melker
Sep 30, 2009·Journal of Women's Health·Kathleen ConroyJessica A Kahn
Sep 19, 2009·Journal of Epidemiology and Community Health·L A V MarlowJ Waller
Jul 8, 2010·American Journal of Health Behavior·Jennifer M GierischNoel T Brewer
Jun 13, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·B M AuduT Z Swende

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