Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.

European Journal of Nuclear Medicine and Molecular Imaging
Iina LaitinenJuhani Knuuti

Abstract

The ligand [(11)C]PK11195 binds with high affinity and selectivity to peripheral benzodiazepine receptor, expressed in high amounts in macrophages. In humans, [(11)C]PK11195 has been used successfully for the in vivo imaging of inflammatory processes of brain tissue. The purpose of this study was to explore the feasibility of [(11)C]PK11195 in imaging inflammation in the atherosclerotic plaques. The presence of PK11195 binding sites in the atherosclerotic plaques was verified by examining the in vitro binding of [(3)H]PK11195 onto mouse aortic sections. Uptake of intravenously administered [(11)C]PK11195 was studied ex vivo in excised tissue samples and aortic sections of a LDLR/ApoB48 atherosclerotic mice. Accumulation of the tracer was compared between the atherosclerotic plaques and non-atherosclerotic arterial sites by autoradiography and histological analyses. The [(3)H]PK11195 was found to bind to both the atherosclerotic plaques and the healthy wall. The autoradiography analysis revealed that the uptake of [(11)C]PK11195 to inflamed regions in plaques was more prominent (p = 0.011) than to non-inflamed plaque regions, but overall it was not higher than the uptake to the healthy vessel wall. Also, the accumulation of (11)...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M W McEneryS H Snyder
Jan 1, 1987·Annals of the New York Academy of Sciences·F Zavala, M Lenfant
Nov 27, 1984·European Journal of Pharmacology·F ZavalaM Lenfant
Jan 1, 1993·Life Sciences·A L ParolaH E Laird
Jul 1, 1997·The Journal of Clinical Investigation·M M VéniantS G Young
Feb 19, 2002·Neurochemistry International·Pierre CasellasAnthony S Basile
Sep 10, 2002·Toxicology and Applied Pharmacology·Hazel A JonesChristopher Haslett
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C DebruyneJ L De Reuck
May 24, 2003·The European Respiratory Journal·H A JonesN W Morrell
Jun 10, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed TawakolAlan J Fischman
Jul 18, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Iina LaitinenJuhani Knuuti

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Citations

Jun 5, 2013·Journal of Cardiovascular Translational Research·Johan W Verjans, Farouc A Jaffer
Jan 13, 2012·European Heart Journal·Juan Carlos Kaski
Oct 5, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mahmoud RazavianMehran M Sadeghi
Dec 20, 2012·Oxidative Medicine and Cellular Longevity·Xiaolong QiJunjie Xiao
Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging· Johanna HaukkalaAnne Roivainen
Jan 15, 2014·JACC. Cardiovascular Imaging·Ambros J BeerMarkus Schwaiger
Jan 22, 2015·Future Cardiology·Jason M TarkinJames H F Rudd
Aug 14, 2010·Journal of the American College of Cardiology·Francesca PugliesePaolo G Camici
Jan 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jasmina Dimitrova-ShumkovskaMoshe Gavish
Apr 25, 2016·Current Atherosclerosis Reports·Nicholas R EvansJames H F Rudd
Jun 30, 2015·PloS One·Miikka TarkiaJuhani Knuuti
May 27, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sanna HellbergAntti Saraste
Jun 11, 2014·Nature Reviews. Cardiology·Jason M TarkinJames H F Rudd
Sep 12, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Soo Jin Lee, Jin Chul Paeng
Oct 7, 2017·Nature Reviews. Neurology·Nicholas R EvansElizabeth A Warburton
Jun 25, 2019·Cardiovascular Research·Mark G MacAskillAdriana A S Tavares
Feb 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos Pérez-MedinaWillem J M Mulder
Jul 9, 2020·International Journal of Molecular Sciences·László PotorJózsef Balla
Dec 16, 2011·Journal of Cardiovascular Translational Research·Leonarda GaliutoFilippo Crea
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Iina E K LaitinenAnne Roivainen

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