PMID: 6412562Sep 1, 1983Paper

Uptake of latex particles by pulmonary macrophages: role of calcium

The American Journal of Physiology
R J Parod, J D Brain

Abstract

The uptake of latex particles by both viable and fixed hamster pulmonary macrophages was calcium and trypsin sensitive. Particle uptake did not stimulate the uptake of 45Ca. However, when 45Ca uptake was stimulated with A23187, particle uptake was inhibited. When cobalt was added with A23187, the uptake of 45Ca was inhibited and particle uptake returned to control levels. A23187, cytochalasin B, and A23187 plus cytochalasin B all reduced particle uptake to the same extent. Although both A23187 and ouabain produced similar changes in the intracellular levels of Na+ and K+, only A23187 inhibited particle uptake. We conclude that extracellular Ca2+ promotes particle-cell binding through its interaction with a trypsin-sensitive receptor in the pulmonary macrophage membrane. In contrast, elevated intracellular Ca2+ levels inhibit particle ingestion but not attachment.

References

Jan 1, 1977·Annual Review of Biochemistry·S C SilversteinZ A Cohn
Aug 1, 1977·Biochimica Et Biophysica Acta·D Hemmaplardh, E H Morgan
Jan 1, 1976·Annual Review of Biochemistry·B C Pressman
Dec 1, 1975·Journal of Cellular Physiology·E K GallinA S Rosenthal
Mar 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R I Kavet, J D Brain
Jan 1, 1969·Annual Review of Physiology·J M Diamond, E M Wright
Aug 4, 1971·Nature: New Biology·A C AllisonS De Petris
Dec 1, 1981·The Journal of Cell Biology·S B HorwitzO M Rosen
Apr 14, 1980·Biochemical and Biophysical Research Communications·G A Warr
Jan 1, 1980·Scandinavian Journal of Immunology·R van Furth, M M Diesselhoff-den Dulk

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Citations

Mar 1, 1993·Photochemistry and Photobiology·M LeviE Gratton
Nov 22, 2001·The Journal of Biological Chemistry·Pierre Emmanuel MilhietChristian Le Grimellec
Aug 1, 1991·Environmental Health Perspectives·A G Heppleston
Sep 1, 1995·Scandinavian Journal of Immunology·M IchinoseM Sawada
Sep 6, 1994·Chemistry and Physics of Lipids·R Welti, M Glaser
Feb 23, 1993·Biochimica Et Biophysica Acta·L S RamsammyG J Kaloyanides
Jul 11, 1985·Biochimica Et Biophysica Acta·B R Kurnik, K A Hruska
Nov 13, 1991·Biochimica Et Biophysica Acta·P Proulx
Jul 22, 1991·Biochimica Et Biophysica Acta·M A Pérez-AlbarsanzM N Recio
Aug 27, 1985·Biochimica Et Biophysica Acta·G CarmelC Le Grimellec
Aug 23, 1988·Biochemistry·K Simons, G van Meer

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