PMID: 4597735Jun 1, 1973

Uptake of minocycline and tetracycline by tetracycline-susceptible and -resistant bacteria

Antimicrobial Agents and Chemotherapy
N A Kuck, M Forbes

Abstract

Minocycline (7-dimethylamino-6-demethyl-6-deoxytetracycline) is a new semisynthetic tetracycline with potent activity against tetracycline-susceptible bacterial pathogens and unique activity against tetracycline-resistant staphylococci. Studies to determine the basis for this unique activity showed that, whereas tetracycline-resistant staphylococci took up less (3)H-tetracycline than the susceptible cells, both the tetracycline-resistant and -susceptible cells accumulated equivalent amounts of (14)C-minocycline. In contrast, tetracycline-resistant Escherichia coli cells were relatively resistant to minocycline and accumulated less of both drugs than did the susceptible organisms. It is proposed that minocycline is effective against tetracycline-resistant staphylococci because of its ability to penetrate the cells sufficiently to reach inhibiting concentrations at sensitive reaction sites.

References

Mar 1, 1968·The American Journal of the Medical Sciences·N H SteigbigelM Finland
Apr 1, 1968·The American Journal of the Medical Sciences·J FedorkoH Allnoch
Jan 1, 1971·The Journal of Pharmacy and Pharmacology·W B HugoJ R Davidson
Jan 1, 1966·Journal of General Microbiology·W B Hugo, R J Stretton
May 1, 1968·The American Journal of the Medical Sciences·N H SteigbigelM Finland
Oct 1, 1969·Journal of Pharmaceutical Sciences·J L Colaizzi, P R Klink
Aug 1, 1970·Journal of General Microbiology·D SompolinskyN Abramova
Feb 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·N A KuckM Forbes
Jul 1, 1968·Journal of Comparative Pathology·A G Jabara
Aug 4, 1966·The New England Journal of Medicine·S A Kabins, S Cohen
Jan 1, 1967·Journal of Medicinal Chemistry·M J Martell, J H Boothe

Citations

Nov 1, 1974·Antimicrobial Agents and Chemotherapy·J P PhairJ Carleton
Apr 1, 1976·Antimicrobial Agents and Chemotherapy·S SchaeflerC L Ruby
May 14, 2017·Pharmacological Reports : PR·Hamed Haghi-AminjanMohammad Abdollahi

Related Concepts

Antibiotic Resistance, Microbial
Alkalescens-Dispar Group
Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer
Genus staphylococcus
Tetrabid

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