Uptake of systematic reviews and meta-analyses based on individual participant data in clinical practice guidelines: descriptive study

BMJ : British Medical Journal
Claire L ValeCochrane IPD Meta-analysis Methods Group

Abstract

To establish the extent to which systematic reviews and meta-analyses of individual participant data (IPD) are being used to inform the recommendations included in published clinical guidelines. Descriptive study. Database maintained by the Cochrane IPD Meta-analysis Methods Group, supplemented by records of published IPD meta-analyses held in a separate database. A test sample of systematic reviews of randomised controlled trials that included a meta-analysis of IPD, and a separate sample of clinical guidelines, matched to the IPD meta-analyses according to medical condition, interventions, populations, and dates of publication. Descriptive information on each guideline was extracted along with evidence showing use or critical appraisal, or both, of the IPD meta-analysis within the guideline; recommendations based directly on its findings and the use of other systematic reviews in the guideline. Based on 33 IPD meta-analyses and 177 eligible, matched clinical guidelines there was evidence that IPD meta-analyses were being under-utilised. Only 66 guidelines (37%) cited a matched IPD meta-analysis. Around a third of these (n=22, 34%) had critically appraised the IPD meta-analysis. Recommendations based directly on the matched IP...Continue Reading

Citations

Oct 31, 2015·Academic Pediatrics·Ruth E K SteinSarah McCue Horwitz
Apr 28, 2016·BMC Medical Research Methodology·Areti Angeliki VeronikiAndrea C Tricco
Dec 5, 2017·The Proceedings of the Nutrition Society·Taryn J SmithKathryn H Hart
Aug 14, 2018·Journal of Magnetic Resonance Imaging : JMRI·Trevor A McGrathMatthew D F McInnes
Nov 18, 2018·International Journal of Epidemiology·Ewoud SchuitJohn P A Ioannidis
Oct 28, 2017·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Mehran MidiaJeff Muir
Aug 11, 2020·Medical Teacher·Tanya HorsleyRachel H Ellaway
May 14, 2020·BMC Medical Research Methodology·Matthew VentrescaMatthias Briel
Aug 2, 2017·Intensive Care Medicine·Yaseen M Arabi, Jean-Charles Preiser
Mar 30, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Ana FerroNuno Lunet

❮ Previous
Next ❯

Software Mentioned

Cochrane
GRADE
AGREE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Trials : Journal of the Society for Clinical Trials
Mark C SimmondsSimon Thompson
Nederlands tijdschrift voor geneeskunde
G E BekkeringFrank Buntinx
Medicina clínica
Gerard UrrutiaQUOROM group
Implementation Science : IS
Sharon Hakkennes, Sally Green
© 2022 Meta ULC. All rights reserved