Uptake of the hormone 1,25-dihydroxyvitamin D3 by the dog liver

Canadian Journal of Physiology and Pharmacology
M Gascon-BarréP M Huet

Abstract

The hepatic uptake of the hormone 1,25-dihydroxyvitamin D3 has been studied, in vivo, using the multiple indicator dilution technique. The fractional uptake of 1,25-dihydroxyvitamin D3 during a single circulatory passage across the dog liver has been estimated at 34.4 +/- 3.3% while its hepatic clearance was estimated at 364.3 +/- 94.1 mL/min. The hepatic uptake of 1,25-dihydroxyvitamin D3 is discussed in relation to its systemic bioavailability following intravenous or oral administration as well as in relation to the hepatic uptake of other vitamin D sterols; it is postulated that the hepatic uptake of vitamin D sterols does not seem to be mediated by specific receptors on the liver plasma membrane; it seems, however, that the hepatic uptake of vitamin D sterols may be inversely related to their relative affinity for the circulating carrier, the vitamin D binding protein.

Citations

Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marielle Gascon-BarréAntonio Nanci
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Catherine TheodoropoulosMarielle Gascon-Barre

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