Uptake of the pharmaceutical Fluoxetine Hydrochloride from growth medium by Brassicaceae

Phytochemistry
Clare H RedshawSteven J Rowland

Abstract

Since the European Union banned disposal of sewage sludge (SS) at sea in 1998 the application rate of SS to land has risen significantly. Land application is thus possibly an important transport route for SS-associated organic chemicals, including pharmaceuticals, to soils and perhaps also to plants. The potential for the selective serotonin re-uptake inhibitor, Fluoxetine HCl, to undergo uptake into Brassicaceae tissues was therefore investigated in a tissue culture study under laboratory conditions for 12 weeks. From growth medium containing 280 ng Fluoxetine HCl mL(-1), translocation into Brassica oleracea var. botrytis (cauliflower) stems (5% mean uptake of applied burden; 0.49 microg g wet weight(-1)) and leaves (3% mean uptake; 0.26 microg g wet weight(-1)) was confirmed, but no evidence of uptake into the curd was found; other possible explanations of the observations are also discussed. Although the data for individual plants were highly variable, as was the recovery of spiked internal standard (deuterated Fluoxetine HCl), the results nonetheless suggest uptake of Fluoxetine may indeed be a potential transport route to plants. A similar study of uptake from soils rather than from an artificial medium should now be under...Continue Reading

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Citations

Jan 1, 2013·Environmental Science and Pollution Research International·Dong Qing ZhangSoon Keat Tan
Sep 26, 2012·Journal of Agricultural and Food Chemistry·Rumi TanoueKei Nomiyama
Feb 1, 2014·Environmental Science and Pollution Research International·Pedro N CarvalhoHans Brix
Jan 29, 2016·Journal of Pharmaceutical and Biomedical Analysis·Anna Białk-BielińskaPiotr Stepnowski
Dec 1, 2015·Environmental Science & Technology·Elizabeth L MillerJoel A Pedersen
Aug 8, 2012·Journal of Chromatography. a·Xiaoqin WuJay Gan
Aug 9, 2015·The Science of the Total Environment·Xiaoqin WuJay Gan
Apr 26, 2011·Ecotoxicology and Environmental Safety·Adcharee KarnjanapiboonwongTodd A Anderson
Jun 13, 2012·The Science of the Total Environment·Lyne SabourinEdward Topp
Jul 13, 2013·Environmental Pollution·Dong Qing ZhangSoon Keat Tan
Oct 2, 2013·Environmental Pollution·Dongqing ZhangSoon Keat Tan
Jan 11, 2014·Journal of Agricultural and Food Chemistry·Laura J CarterAlistair B A Boxall

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