Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Isabella RimoldiA Pessina

Abstract

In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisPt). Mesenchymal Stromal Cells (AT-MSCs) showed a significant different sensitivity (IC50 = 71.9 ± 15.1 μM for caPt(II)-complex and 8.7 ± 4.5 μM for CisPt) to the antiproliferative activity of caPt(II)-complex and CisPt. The ability of MSCs to uptake both the drugs in a similar amount of 2.49 pM /cell, suggested a possible development of new therapies based on cell mediated drug delivery.

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Citations

Sep 25, 2018·Expert Opinion on Therapeutic Patents·Francesco PetrellaLorenzo Spaggiari
May 13, 2020·Archiv der Pharmazie·Emanuela CorsiniMichael S Christodoulou
Aug 15, 2020·Frontiers in Bioengineering and Biotechnology·Amirhesam BabajaniHassan Niknejad
Oct 9, 2020·European Radiology Experimental·Stefania RizzoFrancesco Petrella
Dec 14, 2019·Bioorganic & Medicinal Chemistry Letters·Michael S ChristodoulouSabrina Giofrè
Aug 8, 2021·International Journal of Molecular Sciences·Robert CzarnomysyKrzysztof Bielawski

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