Urachal inflammatory myofibroblastic tumor with ALK gene rearrangement: a study of urachal remnants

Urology
Alessandra F NascimentoVânia Nosé

Abstract

Abnormalities of the urachus are rare among children and include a patent tract and cyst formation. These structures can also be affected by infection and abscess development. They are usually diagnosed during infancy and treated by surgical resection. Involvement of this remnant by either benign or malignant tumors is very infrequent. A few cases of mesenchymal tumors, such as desmoid tumor and leiomyoma, involving the urachus have been described in published reports. We studied an inflammatory myofibroblastic tumor arising from the urachus in a 10-year-old boy. In addition, we reviewed 101 cases of urachal remnants retrieved from the surgical pathology and autopsy files in the Department of Pathology at the Children's Hospital Boston diagnosed in the past 82 years. The urachal inflammatory myofibroblastic tumor showed anaplastic lymphoma kinase (ALK) rearrangement by immunohistochemistry and fluorescence in situ hybridization techniques. No other neoplasms were diagnosed in the analyzed population. We describe an example of inflammatory myofibroblastic tumor involving the urachus. Involvement of the urachus by tumors is rare, but these should be considered in the differential diagnosis of urachal lesions.

References

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Citations

Sep 6, 2007·Pediatric Hematology and Oncology·Eudaldo M López-Tomassetti FernándezLucio Díaz Flores
Aug 21, 2007·The Journal of Urology·Richard A AshleyStephen A Kramer
Jan 7, 2011·Journal of the American Academy of Nurse Practitioners·Cherese R Severson
Apr 29, 2015·Journal of Pediatric Surgery·Alaa CheikhelardSabine Sarnacki
Nov 11, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Carolina Parada VillavicencioFrank H Miller
Jun 21, 2016·Journal of Pediatric Hematology/oncology·T L SumaM N Suma
Feb 5, 2021·Urology Case Reports·Rose GeorgeBadar M Mian

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