Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease.

Journal of Comparative Pathology
Mizael MachadoMarcio B Castro

Abstract

Uraemic encephalopathy (UE) is rarely associated with acute kidney injury or chronic kidney disease in domestic animals, and we now report the first case in a cat. The animal presented with hypothermia, apathy, lethargy, depression, severe dehydration, uraemic breath, elevated serum urea nitrogen and creatine concentrations, and eventual seizures and coma prior to death. Gross necropsy findings included severe bilateral renal scarring, ulcerative stomatitis and glossitis, and uraemic gastropathy. Microscopic lesions of diffuse interstitial fibrosis, multifocal mineralization and lymphoplasmacytic interstitial nephritis were seen in the kidneys. There was symmetrical, bilateral spongy vacuolation of the white matter of the basal nuclei and cerebellum and Alzheimer type II astrocytes in the cerebral cortex and hippocampus. Glial fibrillary acid protein immunolabelling was absent or faint in astrocytes of the cerebral grey matter. UE should be included in the differential diagnosis in animals with chronic kidney disease and neurological signs.

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
I ROBERTSON, M KEMP
BMJ Case Reports
Arunmozhimaran Elavarasi, Vinay Goyal
BMJ Case Reports
Hiroyuki Yano, Mitsuyo Kinjo
Proceedings of the European Dialysis and Transplant Association
J Bergstroöm
© 2021 Meta ULC. All rights reserved