Urapidil, a dual-acting antihypertensive agent: Current usage considerations

Advances in Therapy
Jan Buch

Abstract

Despite the availability of a wide range of effective blood pressure (BP)-lowering agents, a substantial proportion of patients with hypertension fail to achieve target BP levels. The majority of patients with hypertension need a combination of two or more drugs to achieve BP targets and choice of second-line or subsequent-line therapy is an important consideration in hypertension management. Alpha-1-adrenoreceptor antagonists (alpha-blockers) have a BP-lowering effect broadly similar to the other antihypertensive drug classes and are effective as add-on therapy in patients with inadequately controlled hypertension. Alpha-blockers may also have therapeutic benefits that go beyond BP control, including improvements in lipid profile and glucose metabolism, as well as reducing the symptoms of benign prostatic hyperplasia. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT(1A) receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve...Continue Reading

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Citations

Apr 29, 2014·Current Hypertension Reports·Lisa ManningCraig S Anderson
Mar 11, 2015·Hypertension·Mony Fraer, Fusun Kilic
Aug 24, 2017·Pharmaceutical Biology·Yung Sing Ch'ngMun Fei Yam
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Mar 9, 2019·Frontiers in Neurology·Jeffrey R VittJ Claude Hemphill

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