Urapidil, but not dihydropyridine calcium channel inhibitors, preserves the hypoxic pulmonary vasoconstriction: an experimental study in pig arteries

Fundamental & Clinical Pharmacology
Claire BoppPierre Diemunsch

Abstract

Hypoxic pulmonary vasoconstriction (HPV) is a protective mechanism maintaining blood oxygenation by redirecting blood flow from poorly ventilated to well-ventilated areas in the lung. Such a beneficial effect is blunted by antihypertensive treatment with dihydropyridine calcium channel inhibitors. The aim of the present study was to evaluate the effect of urapidil, an antihypertensive agent acting as an α1 adrenergic antagonist and a partial 5-HT1A agonist, on HPV in porcine proximal and distal pulmonary artery rings, and to characterize underlying mechanisms. Rings from proximal and distal porcine pulmonary artery were suspended in organ chambers and aerated with a 95% O2 + 5% CO2 gas mixture. HPV was induced by changing the gas to a 95% N2 + 5% CO2 mixture following a low level of pre-contraction with U46619. Hypoxia induced a contractile response in both proximal and distal pulmonary artery rings. This effect is observed in the presence of a functional endothelium and is inhibited by a soluble guanylyl cyclase inhibitor (ODQ), a NO scavenger (carboxy-PTIO), and by catalase in proximal pulmonary artery rings. The endothelium-dependent HPV is prevented by nicardipine and clevidipine but remained unaffected by urapidil in both ...Continue Reading

References

Mar 1, 1990·Trends in Pharmacological Sciences·P R Saxena, C M Villalón
Jul 7, 1988·European Journal of Pharmacology·G GrossC Rugevics
Feb 1, 1983·The Journal of Physiology·J G De Mey, P M Vanhoutte
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·P J PearsonP M Vanhoutte
Nov 14, 1997·Anesthesia and Analgesia·C HurauxJ H Levy
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Q LiuJ T Sylvester
Jan 18, 2002·Journal of Applied Physiology·Yoshiteru Morio, Ivan F McMurtry
Dec 16, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jian WangJ T Sylvester
Jan 25, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jian WangJ T Sylvester
Nov 12, 2005·The New England Journal of Medicine·E Kenneth WeirStephen L Archer
Jan 14, 2012·Revue de pneumologie clinique·J CotteE Meaudre
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Jun 8, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Zhengju ChenYuansheng Gao
Jul 24, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Yuansheng Gao, Paul M Vanhoutte
Jan 15, 2015·Anesthesiology·Andrew B Lumb, Peter Slinger
Sep 21, 2016·Chest·Kimberly J Dunham-SnaryStephen L Archer

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