PMID: 8608776May 1, 1995Paper

Urban levels of air pollution increase lung responsiveness in rats

Environmental Research
P M PereiraM A Martins

Abstract

This study was designed to investigate if animals exposed to urban levels of air pollution develop pulmonary hyperresponsiveness and to test if this change was reversed after moving the animals to a nonpolluted environment. One hundred twenty male Wistar rats were kept in (a) São Paulo (polluted environment) for 3 months (SP3); (b) Atibaia (clean region), for 3 months (A3); (c) São Paulo for 3 months and then Atibaia for a further 3 months (SPA6); (d) Atibaia for 6 months (A6). After the exposure period, the rats were submitted to dose-response curves to inhaled methacholine. Older animals (SPA6 and A6) had lower responses to methacholine in terms of respiratory system resistance when compared to the animals studied after 3 months of experiment (SP3 and A3). However, the response in terms of respiratory system elastance of the SP3 group was significantly (P = 0.0004) greater than those of the other three groups. Our results suggest that the environmental conditions of the large urban centers can induce pulmonary hyperresponsiveness in rats that can be reversed when the animals are removed to a nonpolluted area.

Citations

Jan 1, 2003·Archives of Environmental Health·Riccardo PolosaGiuseppe U Di Maria
Jun 10, 1998·Environmental Health Perspectives·L A PereiraP H Saldiva
Mar 26, 2015·American Journal of Respiratory Cell and Molecular Biology·Elizabeth A ThompsonJames C Bonner
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Marc Riedl, David Diaz-Sanchez
Feb 8, 2006·Environmental Research·Ruy Camargo Pires-NetoMarisa Dolhnikoff
Apr 12, 2005·Environmental Research·Soraya Vecci MohallemMarisa Dolhnikoff
May 30, 2008·Biology of Reproduction·Mariana Matera VerasMarisa Dolhnikoff
Mar 24, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S C L FarhatP H N Saldiva
Feb 4, 2003·Current Allergy and Asthma Reports·David Diaz-SanchezRiccardo Polosa
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·S Salvi
May 28, 2005·Environmental Management·Simone Georges El Khouri MiragliaGyörgy Miklós Böhm

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