Urban residence is associated with bronchial hyperresponsiveness in Italian general population samples

Chest
Sara MaioGiovanni Viegi

Abstract

The role of different risk factors for bronchial hyperresponsiveness (BHR), such as gender, atopy, IgE, and environmental factors (smoking, occupational exposure, infections), has been described. Indoor and outdoor pollution play an important role too, but few studies have analyzed the association with BHR. The aim of this study was to assess the effect of urban residence on BHR. We studied two general population samples enrolled in two cross-sectional epidemiological studies performed in Northern Italy (Po Delta, rural area) and Central Italy (Pisa, urban area). We analyzed 2,760 subjects (age range, 8 to 74 years). We performed analysis of variance and logistic regression analysis using ln slope of the dose-response curve of the methacholine challenge test as dependent variable, and sex, age, smoking habits, respiratory symptoms, skin-prick test results, IgE value, residence, and airway caliber as independent variables. The mean value of ln slope of the dose-response curve adjusted for initial airways caliber (by baseline FEV(1) percentage of predicted value) was significantly higher in female subjects, in smokers, in subjects with respiratory symptoms, in younger and older ages, in subjects with high values of IgE, and in su...Continue Reading

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Citations

Apr 7, 2011·Current Opinion in Pediatrics·Daniel A Searing, Nathan Rabinovitch
Nov 29, 2015·Respiratory Medicine·Sara MaioGiovanni Viegi
Jun 27, 2020·Chinese Medical Journal·Giovanni ViegiFrancesco Forastiere
Nov 15, 2020·Journal of Clinical Medicine·Sara Maio On Behalf Of The Agave Pisa Group

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