Urea and protein metabolism in burned children: effect of dietary protein intake

Metabolism: Clinical and Experimental
B W PattersonR R Wolfe

Abstract

The response of urea metabolic kinetics, the rate of whole-body protein breakdown, and muscle and skin protein synthesis rates to dietary protein intake (1.15 to 2.92 g/kg/d) was assessed in children with 20% to 40% total body surface area burn injury using a primed continuous infusion of 15N2-urea and L-13C6-phenylalanine. Plasma urea concentration, production, and excretion rates increased with dietary protein intake without evidence of approaching maximum plateau values. There was no consistent evidence of urea recycling in these subjects (urea production = excretion) at any level of protein intake. The rate of appearance (Ra) of phenylalanine (an index of whole-body protein breakdown) and rate of muscle protein synthesis were independent of dietary protein, whereas there was a significant increase in skin protein synthesis with higher protein intake. We conclude that there seems to be little benefit of high protein intake on whole-body protein breakdown and muscle protein synthesis rates in these burn patients, although high-protein diets may enhance wound healing.

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Citations

Nov 13, 2004·The Journal of Nutritional Biochemistry·M D Peck, Y Chang
Oct 7, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Noe A RodriguezDavid N Herndon
Jan 25, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Juquan SongMarc G Jeschke
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Jul 19, 2002·Chest Surgery Clinics of North America·Katherine Trahan, Dennis C Gore
May 31, 2011·The Surgical Clinics of North America·Felicia N WilliamsDavid N Herndon

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