PMID: 9432352Jul 1, 1997Paper

Urea breath tests for the detection of Helicobacter pylori infection

Helicobacter
F BazzoliE Roda

Abstract

Helicobacter pylori is recognized as an important human pathogen. The urea breath test, using either 13C or 14C, provides a noninvasive diagnostic method for the detection of active H. pylori infection. We review the data regarding the utility of the urea breath test in the diagnosis and follow-up of patients with suspected H. pylori infection. Following its ingestion, labeled urea is hydrolyzed by H. pylori urease, producing ammonia and labeled CO2, which is absorbed and can be detected in expired breath. The urea breath test provides a semiquantitative assessment of the load of H. pylori and overcomes the problem of the sampling error due to the patchy distribution of the infection. 13C-urea breath test has an advantage over the 14C version, because the 13C isotope is a nonradioactive natural isotope; therefore, a user's license is unnecessary, making simple the handling and mailing of samples. The 13C-urea breath test is preferred in children and expectant mothers. The high sensitivity, and specificity of the 13C-urea breath test are such that it can be considered a clinical gold standard against which other diagnostic methods can be validated. This test can be used as the sole method for evaluating the effectiveness of trea...Continue Reading

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Citations

Jan 14, 2000·International Journal of Food Microbiology·M Velázquez, J M Feirtag
Oct 9, 2002·Journal of the American Geriatrics Society·Nathalie Salles-MontaudonJean-Paul Emeriau
Jul 4, 2001·European Journal of Gastroenterology & Hepatology·A LeodolterP Malfertheiner
Feb 11, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F ManaD Urbain
Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Oct 9, 2003·Alimentary Pharmacology & Therapeutics·H O'Connor, S Sebastian
Jul 24, 2002·The American Journal of Gastroenterology·Andreas LeodolterPeter Malfertheiner
Dec 1, 2004·Alimentary Pharmacology & Therapeutics·J P Gisbert, J M Pajares
Oct 13, 2006·Current Opinion in Gastroenterology·Najeeb Zoubi, Chris J Dickinson
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
May 17, 2003·International Journal of Immunopathology and Pharmacology·M M D'EliosG Del Prete
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·C E M De BlockL F Van Gaal
Oct 12, 2001·Current Problems in Pediatric and Adolescent Health Care·B D Gold

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