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Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins

Protein Science : a Publication of the Protein Society

Mar 4, 2010

C Nick PaceG R Grimsley

Abstract

The goal of this article is to gain a better understanding of the denatured state ensemble (DSE) of proteins through an experimental and computational study of their denaturation by urea. Proteins unfold to different extents in urea and the most hydrophobic proteins have the most compac...read more

Mentioned in this Paper

Thermodynamics
Micrococcal Nuclease
Activated T Cell Autonomous Cell Death
Carmol
Urea Measurement
Denaturation
Circular Dichroism, Vibrational
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Urea
Protein Denaturation
Paper Details
References
  • References83
  • Citations23
12345...
  • References83
  • Citations23
123

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Thermodynamics of protein denatured states

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Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins

Protein Science : a Publication of the Protein Society

Mar 4, 2010

C Nick PaceG R Grimsley

PMID: 20198681

DOI: 10.1002/pro.370

Abstract

The goal of this article is to gain a better understanding of the denatured state ensemble (DSE) of proteins through an experimental and computational study of their denaturation by urea. Proteins unfold to different extents in urea and the most hydrophobic proteins have the most compac...read more

Mentioned in this Paper

Thermodynamics
Micrococcal Nuclease
Activated T Cell Autonomous Cell Death
Carmol
Urea Measurement
Denaturation
Circular Dichroism, Vibrational
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Urea
Protein Denaturation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

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Examining the genomics, transcriptomics, proteomics and metabolomics of the human vascular endothelial cells at the single cell level will help build a single cell atlas of human vascular endothelium, which would give a unique ID card for each cell type, a three-dimensional map of how cell types work together to form tissues and insights into how changes in the map underlie health and disease of the vascular endothelium from young to old age. Disocver the latest research on the single cell atlas of human vascular endothelial cell atlas here.

Related Papers

Molecular BioSystems

Thermodynamics of protein denatured states

Molecular BioSystemsJanuary 25, 2007
B E Bowler
Paper Details
References
  • References83
  • Citations23
12345...
  • References83
  • Citations23
123

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