Urea kinetics varies in Jamaican women and men in relation to adiposity, lean body mass and protein intake

European Journal of Clinical Nutrition
S C ChildA A Jackson

Abstract

We have measured urea kinetics in normal adult men and women of different body composition to determine whether adiposity is associated with differences in the rate of urea production or endogenous urea hydrolysis. Urea kinetics were determined from the excretion of [15N15N]urea in urine over a period of 48 h following a single oral dose of [15N15N]urea, in nine lean and nine obese women and in seven light and seven heavy males while they were consuming their habitual diets. Urinary 5-L-oxoproline was measured as an index of glycine metabolic status. The studies were carried out in the research ward of the Tropical Metabolism Research Unit, University of the West Indies. Successful studies were completed in eight obese and five lean women and in six heavy and five light men. When compared with lean women, in obese women the rate of urea production and hydrolysis was significantly greater and this difference could not be accounted for by the greater fat-free mass alone, and was in part associated directly with the increase in fat mass. The rate of urea production and hydrolysis was greater in heavy men than in light men, a difference which was attributed to an increase in dietary protein. In obese women and heavy men there was a...Continue Reading

Citations

Apr 3, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Michael A Singer
Jun 1, 1999·Nutrition Research Reviews·J C Waterlow
Jul 8, 2003·The British Journal of Nutrition·Peter FaberGerald E Lobley
Oct 3, 2014·PLoS Computational Biology·Nathalie PoupinHélène Fouillet
Sep 27, 2002·The American Journal of Clinical Nutrition·Sarah L Duggleby, Alan A Jackson
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A Singer

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