Urea may regulate urea transporter protein abundance during osmotic diuresis

American Journal of Physiology. Renal Physiology
Dongun KimJeff M Sands

Abstract

Rats with diabetes mellitus have an increase in UT-A1 urea transporter protein abundance and absolute urea excretion, but the relative amount (percentage) of urea in total urinary solute is actually decreased due to the marked glucosuria. Urea-specific signaling pathways have been identified in mIMCD3 cells and renal medulla, suggesting the possibility that changes in the percentage or concentration of urea could be a factor that regulates UT-A1 abundance. In this study, we tested the hypothesis that an increase in a urinary solute other than urea would increase UT-A1 abundance, similar to diabetes mellitus, whereas an increase in urine urea would not. In both inner medullary base and tip, UT-A1 protein abundance increased during NaCl- or glucose-induced osmotic diuresis but not during urea-induced osmotic diuresis. Next, rats undergoing NaCl or glucose diuresis were given supplemental urea to increase the percentage of urine urea to control values. UT-A1 abundance did not increase in these urea-supplemented rats compared with control rats. Additionally, both UT-A2 and UT-B protein abundances in the outer medulla increased during urea-induced osmotic diuresis but not in NaCl or glucose diuresis. We conclude that during osmotic ...Continue Reading

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Citations

Nov 17, 2009·Bulletin of Mathematical Biology·Mariano MarcanoHarold E Layton
Oct 24, 2008·American Journal of Physiology. Renal Physiology·Yu-Mi KimDongun Kim
Aug 28, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hui-Ju TsaiWayne H-H Sheu
Mar 31, 2005·American Journal of Physiology. Renal Physiology·Hideki InoueSerena M Bagnasco
Jun 1, 2005·Pflügers Archiv : European journal of physiology·Serena M Bagnasco
Mar 1, 2006·Electrolyte & Blood Pressure : E & BP·Dong-Un Kim
Sep 9, 2006·Journal of the American Society of Nephrology : JASN·Janet D KleinJeff M Sands
Jun 22, 2006·American Journal of Physiology. Renal Physiology·Janet D KleinJeff M Sands
Feb 25, 2020·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Feb 1, 2007·The Journal of Membrane Biology·Serena M Bagnasco
Jun 11, 2009·Physiology·Min Seong KwonH Moo Kwon
May 14, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lotte B BertelsenChristoffer Laustsen
Nov 25, 2004·American Journal of Physiology. Renal Physiology·Hongshi XuDavid M Cohen
Sep 22, 2016·The American Journal of the Medical Sciences·Juan WangJeff M Sands

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