UreA, the major urea/H+ symporter in Aspergillus nidulans

Fungal Genetics and Biology : FG & B
Cecilia AbreuAna Ramon

Abstract

We report here the characterization of UreA, a high-affinity urea/H+ symporter of Aspergillus nidulans. The deletion of the encoding gene abolishes urea transport at low substrate concentrations, suggesting that in these conditions UreA is the sole transport system specific for urea in A. nidulans. The ureA gene is not inducible by urea or its precursors, but responds to nitrogen metabolite repression, necessitating for its expression the AreA GATA factor. In contrast to what was observed for other transporters in A. nidulans, repression by ammonium is also operative during the isotropic growth phase. The activity of UreA is down-regulated post-translationally by ammonium-promoted endocytosis. A number of homologues of UreA have been identified in A. nidulans and other Aspergilli, which cluster in four groups, two of which contain the urea transporters characterized so far in fungi and plants. This phylogeny may have arisen by gene duplication events, giving place to putative transport proteins that could have acquired novel, still unidentified functions.

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Citations

Dec 21, 2013·Fungal Genetics and Biology : FG & B·Emilia Krypotou, George Diallinas
Jan 9, 2016·Environmental Science and Pollution Research International·Ibrahim JuneidiOzair Mohd Ali
Mar 23, 2011·Fungal Genetics and Biology : FG & B·Christos GournasClaudio Scazzocchio
May 5, 2012·The Biochemical Journal·Gerard H M HuysmansStephen A Baldwin
Feb 19, 2020·Biophysics Reviews·Shampa RaghunathanU Deva Priyakumar
Feb 6, 2020·The Biochemical Journal·Maíra Pompeu MartinsNilce Maria Martinez-Rossi
May 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yi DingKemal Kazan
May 17, 2017·Journal of Molecular Graphics & Modelling·Hai-Tian ZhangXiaoqin Zou
Sep 29, 2021·Open Biology·Eszter BokorZsuzsanna Hamari

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