Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.

American Journal of Obstetrics and Gynecology
Timothy J M MossJohn P Newnham

Abstract

The objective of the study was to assess the efficacy of maternal betamethasone for improving preterm lung function in the presence of inflammation induced by amniotic fluid Ureaplasma colonization. Ewes bearing single fetuses were randomized to receive an intraamniotic injection of Ureaplasma parvum (serovar 6; 2 x 10(7) colony-forming units) or vehicle at 86 +/- 2 days of pregnancy (mean +/- SD: term is 150 days), followed by maternal intramuscular betamethasone (0.5 mg/kg) or saline, either 2 or 7 days before delivery of lambs at 123 +/- 1 d. Amniotic fluid interleukin-8 was elevated by ureaplasmas (P = .049) but unaffected by betamethasone. Lung inflammation induced by ureaplasmas was not affected by betamethasone. Lung compliance was increased by Ureaplasma colonization (P = .009) and betamethasone (P = .042), and effects were additive. Lung surfactant was increased by Ureaplasma colonization (P < .001) and betamethasone 7 days (P = .001), but not 2 days, before delivery. Inflammation improves preterm lung function because of increases in surfactant. Antenatal corticosteroids further augment lung function through an apparently independent mechanism.

References

Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·K HannafordG L Gilbert
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Jun 9, 2000·Annual Review of Physiology·A H Jobe, M Ikegami
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·A H JobeM Ikegami
Feb 15, 2001·American Journal of Obstetrics and Gynecology·J E HardingG C Liggins
Aug 3, 2001·American Journal of Obstetrics and Gynecology·J P NewnhamA Jobe
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·B W KramerA H Jobe
Dec 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suhas G KallapurCindy J Bachurski
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Timothy J M MossJohn P Newnham
Feb 24, 2007·Seminars in Perinatology·Robert L Schelonka, Ken B Waites
May 23, 2007·Pediatric Research·Graeme R PolglaseTimothy J M Moss
Jan 2, 2008·American Journal of Obstetrics and Gynecology·Timothy J M MossAlan H Jobe

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Citations

Apr 17, 2013·Clinical and Experimental Pharmacology & Physiology·Danica RyanMary J Black
Feb 5, 2009·Journal of Veterinary Internal Medicine·U ChristmannR D Hite
Oct 12, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer J P CollinsBoris W Kramer
May 25, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Graeme R PolglaseSuhas G Kallapur
Mar 19, 2014·Pediatric Research·Matthew S PayneAlan H Jobe
Nov 22, 2015·Human Reproduction Update·M W KempS J Stock
Mar 17, 2010·Pediatrics and Neonatology·Alan H Jobe
Apr 16, 2013·Seminars in Perinatology·Suhas G KallapurAlan H Jobe
Mar 17, 2012·Reproductive Sciences·Jacqueline M MelvilleTimothy J M Moss
Jun 29, 2010·Reproductive Sciences·Matthew W KempSuhas G Kallapur
Dec 4, 2014·Journal of Developmental Origins of Health and Disease·C J D McKinlayJ E Harding
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bryan F Mitchell, Michael J Taggart
Mar 12, 2010·Pediatric Research·Graeme R PolglaseAlan H Jobe

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