Urease genes in non-O157 Shiga toxin-producing Escherichia coli: mostly silent but valuable markers for pathogenicity

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Alexander W FriedrichH Karch

Abstract

The distribution of ureC was investigated among 294 Escherichia coli isolates, comprising 72 strains from the E. coli standard reference collection (ECOR), 62 strains from the diarrhoeagenic E. coli (DEC) collection, and 160 clinical isolates of Shiga toxin-producing E. coli (STEC). The ureC gene was more frequent among STEC isolates harbouring eae than among those lacking eae (p < 0.0001). All clinical STEC isolates of serogroups O111 and O145 contained ureC, but only two of 294 isolates expressed urease activity. The silencing of urease expression could not be linked to a stop codon in ureD. The frequent occurrence of ure genes in eae-positive STEC isolates makes them valuable markers for virulence.

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Citations

Jun 6, 2012·Infection and Immunity·Susan R Steyert, James B Kaper
Dec 15, 2010·Journal of Bacteriology·Susan R SteyertJames B Kaper
Dec 23, 2015·Toxicon : Official Journal of the International Society on Toxinology·Celia R Carlini, Rodrigo Ligabue-Braun
Nov 7, 2006·Journal of Animal Science·C L Gyles
May 14, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·I FriesemaW van Pelt
May 1, 2021·Pathogens·Shu-Yuan LiPo-Yu Liu

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