Uremia in diabetics: the prognosis improves

Klinische Wochenschrift
E A Friedman, M M Beyer

Abstract

Chronic uremia caused by diabetic glomerulopathy accounts for about 25 percent of new patients treated by maintenance hemodialysis. At the onset of glucose intolerance, insulin dependent diabetics have larger than normal kidneys, with a markedly increased glomerular filtration rate. During the subsequent 15 to 20 years of insulin use, glomerulosclerosis progresses silently, until a clinically overt nephrotic syndrome becomes evident. Thereafter, the clinical manifestations of nephropathy appear rapidly with an exponential decline in creatinine clearance to less than 5 ml/min within one to five years. Putting together a life plan for a nephrotic and azotemic diabetic involves awareness, and coordinated management of not only renal but extrarenal vasculopathic complications of diabetes, especially proliferative retinopathy. Carefully made preparations for hemodialysis and/or renal transplantation with increase changes for at least a short-term favorable outcome, which can now be anticipated in a growing proportion of patients.

References

May 26, 1979·Lancet·R H JonesP J Watkins
Dec 27, 1979·The New England Journal of Medicine·R P Robertson, S A Metz
Jan 1, 1977·Kidney International·W E RutherfordJ D Vavra
Oct 18, 1976·JAMA : the Journal of the American Medical Association·M J KussmanR E Gleason
Jun 1, 1975·Diabetes·A T Paz-GuevaraP White
Jun 1, 1975·Diabetologia·R Osterby, H J Gundersen
Mar 1, 1972·Diabetes·N G Westberg, A F Michael
Feb 6, 1967·JAMA : the Journal of the American Medical Association·R AbellaF Del Greco
Sep 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Oct 1, 1971·Diabetologia·M A BatallaR F Bradley
Sep 1, 1968·The Journal of Clinical Investigation·M D SipersteinL L Madison
Dec 5, 1968·The New England Journal of Medicine·L A BergmanG Dunea
Sep 1, 1953·Diabetes·E T BELL
Feb 20, 1954·Lancet·K LUNDBAEK
Mar 1, 1956·Acta Endocrinologica·D IKKOSR LUFT
Mar 1, 1957·The Journal of Clinical Endocrinology and Metabolism·H GERSHBERGH H STUMPF
Oct 1, 1960·The Journal of Pathology and Bacteriology·R H HEPTINSTALLW BRUMFITT
Jun 1, 1962·The Journal of Clinical Investigation·J CORVILAINA BERGANS
Jun 1, 1962·The Journal of Urology·E H SCHULTZ, E H KLORFEIN
May 19, 1962·Lancet·H KEEN, R K KNIGHT
Sep 1, 1951·The American Journal of Medicine·P IVERSEN, C BRUN
Jul 1, 1949·The American Journal of Medicine·G V MANNH F ROOT

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Transactions - American Society for Artificial Internal Organs
R M HEGSTROMB H SCRIBNER
Journal of the Medical Association of Georgia
J H Sadler
Suomen lääkärilehti. Finlands läkartidning
E HaapanenR Rytkönen
© 2021 Meta ULC. All rights reserved