PMID: 8591056Nov 1, 1995Paper

Uremic acidosis and protein metabolism

Current Opinion in Nephrology and Hypertension
W E Mitch

Abstract

Mechanisms causing loss of lean body mass in uremia include an inability to activate metabolic adaptations to a low-protein diet caused by anorexia, or other factors. The adaptations include decreased degradation of essential amino acids and protein. Metabolic acidosis activates specific pathways which increase catabolism by mechanisms that include stimulation of genes. The inability to adapt to dietary protein restriction causes loss of lean body mass.

Citations

Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T M DonohueS W French
Feb 27, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·X M Leverve
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G R KlegerP E Ballmer
May 24, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M HolecekM Tichý
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Dennis Y WuKamyar Kalantar-Zadeh

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