Uremic cardiomyopathy and insulin resistance: a critical role for akt?

Journal of the American Society of Nephrology : JASN
David SempleAnne-Marie L Seymour

Abstract

Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insulin resistance are defects in insulin signaling through the protein kinase, Akt. Akt acts as a nodal point in the control of both the metabolic and pleiotropic effects of insulin. Imbalance among these effects leads to cardiac hypertrophy, fibrosis, and apoptosis; less angiogenesis; metabolic remodeling; and altered calcium cycling, all key features of uremic cardiomyopathy. Here we consider the role of Akt in the development of uremic cardiomyopathy, drawing parallels from models of hypertrophic cardiac disease.

References

Nov 1, 1979·Kidney International·S G RostandT E Andreoli
Jan 1, 1992·Nephron·R H Mak, R A DeFronzo
Jan 1, 1990·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G MallE Ritz
Aug 1, 1989·Kidney International·J S SilberbergA D Sniderman
Jan 1, 1986·Scandinavian Journal of Urology and Nephrology·N ClyneS K Pehrsson
Sep 1, 1985·Kidney International·R C MayW E Mitch
Apr 1, 1984·Kidney International·S G RostandE A Rutsky
Feb 1, 1981·The Journal of Clinical Investigation·R A DeFronzoJ Wahren
Jun 1, 1995·Journal of the American Society of Nephrology : JASN·R N FoleyP E Barré
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M BuerkeA M Lefer
Apr 1, 1994·Journal of the American Society of Nephrology : JASN·K AmannG Mall
Dec 1, 1993·The Journal of Clinical Investigation·A E RaineJ G Ledingham
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·K ReissP Anversa
Jul 1, 1997·Advances in Renal Replacement Therapy·K Amann, E Ritz
Feb 12, 1998·The Journal of Biological Chemistry·M AndjelkovićB A Hemmings
Jun 11, 1998·Journal of the American Society of Nephrology : JASN·K AmannG Mall
Aug 26, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Aug 27, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K AmannE Ritz
Sep 12, 1998·The Journal of Biological Chemistry·M LaserD Kuppuswamy
Jul 13, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A LevinO Djurdjev
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·P S Parfrey, R N Foley
Jul 21, 1999·Kidney International. Supplement·C A Herzog
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Z A MassyP Jungers
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C DelaughterR J Schwartz
Dec 23, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S KobayashiM Nagase
Jan 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·U SchwarzK Amann
Feb 15, 2000·The Journal of Biological Chemistry·S V Naga PrasadH A Rockman
Feb 17, 2000·The Journal of Clinical Investigation·K CusiL J Mandarino
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·A K JonassenD M Yellon
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·M F AllardG P Bondy
Feb 24, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D Schneditz, N W Levin

❮ Previous
Next ❯

Citations

Oct 11, 2012·The Journal of Biological Chemistry·Jason C ChoiHoward J Worman
Aug 25, 2012·Journal of Biomedicine & Biotechnology·Min-Tser LiaoKuo-Cheng Lu
Aug 9, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christiane DrechslerChristoph Wanner
Apr 26, 2013·Congestive Heart Failure·Eyad AlhajMarc Klapholz
Nov 22, 2013·Journal of Cardiovascular Electrophysiology·Dimitrios PoulikakosMarek Malik
Jan 22, 2013·The Journal of Nutritional Biochemistry·Wei GeJun Ren
Jul 2, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qiurong Wang, Jun Ren
Mar 25, 2017·Expert Opinion on Therapeutic Targets·Xiaoliang WangJoseph I Shapiro
Jan 22, 2019·Nature Reviews. Nephrology·Xiaoliang Wang, Joseph I Shapiro
Dec 6, 2014·Journal of the American Society of Nephrology : JASN·Jian XieChou-Long Huang
Apr 5, 2014·Journal of the American Society of Nephrology : JASN·Rafael KramannGeorg Schlieper
Aug 24, 2012·American Journal of Physiology. Renal Physiology·David J SempleAnne-Marie L Seymour
Jan 15, 2015·American Journal of Physiology. Renal Physiology·David TaylorAnne-Marie L Seymour
Feb 18, 2020·Journal of Cellular and Molecular Medicine·Hung-Yen KeChih-Yuan Lin
Mar 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nan HuJun Ren
Apr 18, 2018·Journal of Cellular Physiology·Kiana Hosseinpour-MoghaddamAmirhossein Sahebkar
Mar 16, 2019·Frontiers in Physiology·Dimitrios PoulikakosMarek Malik
Mar 13, 2021·Clinical Medicine Insights. Cardiology·Kartheek GarikapatiKrishna Echampati

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.