Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney

Artificial Organs
Hsin-Hung LinChiu-Ching Huang

Abstract

Uremic pruritus is one of the common complications in long-term dialysis patients. Recently, researchers reported that immunohypothesis with high serum level of cytokines could be the cause of uremic pruritus. Polymethylmethacrylate (PMMA) artificial kidney (AK) has been reported to adsorb more serum cytokines than other high-flux AKs. In July 2006, 30 patients with severe uremic pruritus from 300 chronic hemodialysis (HD) patients in a single center entered this prospective study. Their dialyzers were changed to PMMA AK for 4 weeks. The severity of pruritus was evaluated every week using the results of a questionnaire (pruritus score). Laboratory assays including predialysis serum blood urea nitrogen (BUN), creatinine, beta2-microglobulin (beta2M), calcium, phosphate, intact parathyroid hormone (iPTH), total CO(2), ferritin, hematocrit, high-sensitivity C-reactive protein (hsCRP), IL-1beta, IL-2, IL-6, IL-18, tumor necrosis factor-alpha (TNF-alpha), Kt/V, and beta2M clearance were measured before and at the end of 4 weeks of PMMA AK use. PMMA AK was effective in reducing the pruritus score from 23.46 +/- 11.94 to 7.38 +/- 6.42 (P < 0.001). The effect of uremic pruritus relief appeared after 1 week of PMMA AK use. There were no...Continue Reading

References

Jul 2, 1998·Kidney International·P L KimmelJ H Veis
Jan 23, 1999·Contributions to Nephrology·K Moriyama, Y Soejima
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Christiane Pauli-MagnusThomas Mettang
Oct 31, 2001·American Journal of Nephrology·A UrbonasJ C Szepietowski
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruno MemoliUNKNOWN Collaborative Study Group on SMC Membrane
Aug 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas MettangDominik Mark Alscher
Jul 31, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter JacobsRaymond Vanholder
Oct 27, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin KimmelThomas Mettang

❮ Previous
Next ❯

Citations

Feb 5, 2009·Nature Clinical Practice. Nephrology·Dirk R J Kuypers
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad Kazem FallahzadehMohammad Reza Namazi
Feb 28, 2009·Artificial Organs·Paul S Malchesky
May 1, 2010·NDT Plus·Filippo Aucella, Antonio Santoro
Jul 2, 2016·Kidney Research and Clinical Practice·Ji-Won MinYong Kyun Kim
May 16, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ayanobu HorinouchiKeiji Tanaka
Jan 29, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yukari OdaKeiji Tanaka
Nov 7, 2018·Renal Failure·Chun-Yang TsengHung-Chih Chen
May 16, 2020·International Journal of Molecular Sciences·Vincenzo LosappioGiovanni Stallone
Mar 26, 2011·Anais Brasileiros De Dermatologia·Elisângela de Quevedo WelterMagda Blessmann Weber
Oct 30, 2020·Canadian Journal of Kidney Health and Disease·Claire E MartinGregory L Hundemer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.