Uremic serum inhibits monocyte-dependent, but not interleukin-2-dependent steps of T cell proliferation

H DumannH Köhler


We examined the influence of uremic serum on antigen receptor triggered T cell proliferation in dialysis patients with impaired immune function, i.e., 12 nonresponders to hepatitis B vaccination. The dialysis patients showed a monocyte dysfunction and an increased responsiveness to interleukin 2 (IL-2) according to our previous findings. In vitro the addition of IL-2 completely reconstituted the defect. Uremic serum inhibited monocyte-dependent T cell proliferation of patients and of healthy controls. Contrary, monocyte-independent steps of T cell proliferation were not impaired by uremic serum. When IL-2 was added to cultures, the T cell proliferation in the presence of uremic serum was even enhanced. We conclude that uremic immunodeficiency may be enhanced by soluble factors present in uremic serum which inhibit monocyte-dependent steps of T cell proliferation.


Aug 23, 2001·International Journal of Antimicrobial Agents·M Kozioł-MontewkaM Majdan
Oct 1, 1992·European Journal of Clinical Investigation·Z RamićM L Lukić
Sep 1, 1996·Kidney International·Y Le MeurV Praloran
Mar 25, 2006·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Terumi HiguchiKoichi Matsumoto

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